ArticleScientific reports2019
Steroid receptors and their regulation in avian extraembryonic membranes provide a novel substrate for hormone mediated maternal effects.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Do Egg Hormones Have Fitness Consequences in Wild Birds? A Systematic Review and Meta-Analysis.Ecology letters · 2025Pooled it
- Liver X Receptor α (LXRα) Regulates 5β-Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Elevating Testosterone and Androstenedione Produces Temporary Sex-Dependent Variation in Japanese Quail (Coturnix japonica) Embryonic Development.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Avian extraembryonic membranes respond to yolk corticosterone early in development.Biology open · 2024Article
- Early conversion of maternal androgens affects the embryo already in the first week of development.Biology letters · 2023Article
- Who listens to mother? A whole-family perspective on the evolution of maternal hormone allocation.Biological reviews of the Cambridge Philosophical Society · 2021Review
- Maternally derived hormones, neurosteroids and the development of behaviour.Proceedings. Biological sciences · 2021Article
- Revisiting mechanisms and functions of prenatal hormone-mediated maternal effects using avian species as a model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure of the vertebrate embryo to maternal hormones can have long-lasting effects on its phenotype, which has been studied extensively by experimentally manipulating maternal steroids, mostly androgens, in bird eggs. Yet, there is a severe lack of understanding of how and when these effects are actually mediated, hampering both underlying proximate and ultimate explanations. Here we report a novel finding that the embryo expresses androgen receptor (AR) and estrogen receptor (ERα) mRNA in its extraembryonic membranes (EMs) as early as before its own hormone production starts, suggesting a novel substrate for action of maternal hormones on the offspring. We also report the first experimental evidence for steroid receptor regulation in the avian embryo in response to yolk steroid levels: the level of AR is dependent on yolk androgen levels only in the EMs but not in body tissues, suggesting embryonic adaptation to maternal hormones. The results also solve the problem of uptake of lipophilic steroids from the yolk, why they affect multiple traits, and how they could mediate maternal effects without affecting embryonic sexual differentiation.
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