Evidence map›Paper›PMID 31395869›Full record

ArticleNature communications2019

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.

Florian Bonkhofer, Rossella Rispoli, Philip Pinheiro, Monika Krecsmarik, Janina Schneider-Swales, Ingrid Ho Ching Tsang, Marella de Bruijn, Rui Monteiro, Tessa Peterkin, Roger Patient

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

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  7. Jund orchestratesProceedings of the National Academy of Sciences of the United States of America · 2025
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  18. The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Florian BonkhoferMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Rossella RispoliMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Philip PinheiroMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Monika KrecsmarikMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Janina Schneider-SwalesMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Ingrid Ho Ching TsangMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Marella de BruijnMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Rui MonteiroMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. r.monteiro@bham.ac.uk.ORCID http://orcid.org/0000-0002-4223-8506
Tessa PeterkinMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Roger PatientMolecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. roger.patient@imm.ox.ac.uk.
John Radcliffe Hospital · GBBharat Heavy Electricals (India) · INGuy's and St Thomas' NHS Foundation Trust · GB

Funding

British Heart Foundation PG/09/082/28020British Heart Foundation PG/14/39/30865Medical Research Council G0902418Medical Research Council MC_U137981013Medical Research Council MC_UU_00016/2Medical Research Council MC_UU_00016/8Medical Research Council MC_UU_12009/2Medical Research Council MC_UU_12009/8
6 · The paper itself

Abstract

Haematopoietic stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aorta (DA). Despite being integral to arteries, it is controversial whether HE and arterial endothelium share a common lineage. Here, we present a transgenic zebrafish runx1 reporter line to isolate HE and aortic roof endothelium (ARE)s, excluding non-aortic endothelium. Transcriptomic analysis of these populations identifies Runx1-regulated genes and shows that HE initially expresses arterial markers at similar levels to ARE. Furthermore, runx1 expression depends on prior arterial programming by the Notch ligand dll4. Runx1

Indexed as

AnimalsAnimals, Genetically ModifiedArteriesCell LineageCore Binding Factor Alpha 2 SubunitEmbryonic DevelopmentEmbryo, NonmammalianEndothelium, VascularGene Knockout TechniquesHemangioblastsIntracellular Signaling Peptides and ProteinsZebrafishZebrafish ProteinsCore Binding Factor Alpha 2 SubunitDll4 protein, zebrafishIntracellular Signaling Peptides and Proteinsrunx1 protein, zebrafishZebrafish Proteins

Identifiers

PMID31395869
PMCPMC6687740
OpenAlexW2966647200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.