ArticleNature communications2019
Bis-naphthopyrone pigments protect filamentous ascomycetes from a wide range of predators.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- BioprospectingFrontiers in fungal biology · 2021Pooled it
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- Soil Allies: Exploring the Combined Potential of Folsomia candida and Trichoderma spp. Against Fusarium oxysporum.Environmental microbiology reports · 2025Article
- Biosynthesis of the Paecilomyces marquandii conidial pigment saintopin.Fungal biology and biotechnology · 2025Article
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- Chemistry and biology of marine-derived Trichoderma metabolites.Natural products and bioprospecting · 2024Review
- Ecological functions of fungal sesquiterpenes in the food preference and fitness of soil Collembola.Royal Society open science · 2024Article
- The Role of Mycotoxins in Interactions betweenToxins · 2023Article
- Identification of Virulence Factors in EntomopathogenicMicroorganisms · 2023Article
- Anti-Insect Properties ofMicroorganisms · 2023Review
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- Phoenicin Switch: Discovering the Trigger for Radical Phoenicin Production in Multiple Wild-TypeApplied and environmental microbiology · 2022Article
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- High Diversity of Type I Polyketide Genes inJournal of fungi (Basel, Switzerland) · 2022Article
- Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study.Marine drugs · 2022Article
- Fungal quinones: diversity, producers, and applications of quinones from Aspergillus, Penicillium, Talaromyces, Fusarium, and Arthrinium.Applied microbiology and biotechnology · 2021Review
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is thought that fungi protect themselves from predation by the production of compounds that are toxic to soil-dwelling animals. Here, we show that a nontoxic pigment, the bis-naphthopyrone aurofusarin, protects Fusarium fungi from a wide range of animal predators. We find that springtails (primitive hexapods), woodlice (crustaceans), and mealworms (insects) prefer feeding on fungi with disrupted aurofusarin synthesis, and mealworms and springtails are repelled by wheat flour amended with the fungal bis-naphthopyrones aurofusarin, viomellein, or xanthomegnin. Predation stimulates aurofusarin synthesis in several Fusarium species and viomellein synthesis in Aspergillus ochraceus. Aurofusarin displays low toxicity in mealworms, springtails, isopods, Drosophila, and insect cells, contradicting the common view that fungal defence metabolites are toxic. Our results indicate that bis-naphthopyrones are defence compounds that protect filamentous ascomycetes from predators through a mechanism that does not involve toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.