Evidence map›Paper›PMID 31395743›Full record

ArticleScience (New York, N.Y.)2019

Structure elucidation of colibactin and its DNA cross-links.

Mengzhao Xue, Chung Sub Kim, Alan R Healy, Kevin M Wernke, Zhixun Wang, Madeline C Frischling, Emilee E Shine, Weiwei Wang, Seth B Herzon, Jason M Crawford

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 1 synthesis or guideline pooled it, 258 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Microbiome-Genome Crosstalk in Colorectal Cancer: Colibactin Signatures andInternational journal of molecular sciences · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mengzhao Xue *Department of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-3752-0352
Chung Sub Kim *Department of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-9961-4093
Alan R HealyDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-1231-8353
Kevin M WernkeDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-8392-0061
Zhixun WangDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-5688-5002
Madeline C FrischlingDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-4551-7196
Emilee E ShineChemical Biology Institute, Yale University, West Haven, CT 06516, USA.ORCID 0000-0002-1290-2496
Weiwei WangDepartment of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-3995-2095
Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT 06520, USA. jason.crawford@yale.edu seth.herzon@yale.edu.ORCID 0000-0001-5940-9853
Jason M CrawfordDepartment of Chemistry, Yale University, New Haven, CT 06520, USA. jason.crawford@yale.edu seth.herzon@yale.edu.ORCID 0000-0002-7583-1242
Yale University · USW. M. Keck Foundation · US

Funding

Predoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4M
Structural and functional studies of colibactinR01CA215553 · NCI · YALE UNIVERSITY · PI Seth B. Herzon, Christian Jobin · 2018 to 2026
$5.5M
Cryptic gut bacterial metabolites that regulate colorectal cancer formationDP2CA186575 · NCI · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2013 to 2013
$2.5M
Synthesis and Study of Complex Antiproliferative and Antimalarial Natural ProductsR01GM110506 · NIGMS · YALE UNIVERSITY · PI HERZON, SETH B. · 2015 to 2018
$1.2M
An Ultra-Performance Liquid Chromatography System to Support Metabolomics at Yale UniversityS10OD019967 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2015 to 2015
$135k
NCI NIH HHS DP2 CA186575NCI NIH HHS R01 CA215553NIGMS NIH HHS R01 GM110506NIGMS NIH HHS T32 GM067543NIH HHS S10 OD019967
6 · The paper itself

Abstract

Colibactin is a complex secondary metabolite produced by some genotoxic gut

Indexed as

DNA AdductsEscherichia coliEscherichia coli ProteinsIsotope LabelingMutationPeptide HydrolasesPeptidesPolyketidesProtein ConformationSecondary MetabolismTandem Mass SpectrometryClbP protein, E colicolibactinDNA AdductsEscherichia coli ProteinsPeptide HydrolasesPeptidesPolyketides

Identifiers

PMID31395743
PMCPMC6820679
OpenAlexW2967933500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.