ArticleGenes & development2019
Rationale for targeting BCL6 in
Open access · diamondAbstract read
In one paragraph
Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Fusion oncoproteins orchestrate tumorigenesis and sustain malignant progression via a positive feedback mechanism.Cell & bioscience · 2026Review
- Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma.Genes & diseases · 2025Article
- DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition.Leukemia · 2025Article
- Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects.Frontiers in immunology · 2025Article
- Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia.Genome biology · 2024Article
- Rewiring cancer drivers to activate apoptosis.Nature · 2023Article
- Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.ACS medicinal chemistry letters · 2023Article
- Small-molecule BCL6 inhibitor protects chronic cardiac transplant rejection and inhibits T follicular helper cell expansion and humoral response.Frontiers in pharmacology · 2023Article
- Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of theMolecular therapy oncolytics · 2022Article
- Identification BCL6 and miR-30 family associating with Ibrutinib resistance in activated B-cell-like diffuse large B-cell lymphoma.Medical oncology (Northwood, London, England) · 2021Article
- Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib.International journal of molecular sciences · 2021Article
- The MLL/SET family and haematopoiesis.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Christian Hurtz *Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Lai N Chan *Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Huimin GengDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Erica BallabioMedical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.
Gang XiaoDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Gauri DebDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Haytham KhouryDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Chun-Wei ChenDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Scott A ArmstrongDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jianjun ChenDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
Patricia ErnstDepartment of Pediatrics, University of Colorado, Denver, Colorado 80045, USA.
Ari MelnickDepartment of Medicine, Weill Cornell Medical College, New York, New York 10065, USA.
Thomas MilneMedical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.ORCID 0000-0002-0413-4271
Markus MüschenDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.
University of California, San Francisco · USCity of Hope · USUniversity of Oxford · GBCornell University · USHarvard University · USUniversity of Colorado Denver · US
Funding
TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5MThe Center for Therapeutic Targeting of EWS-oncoproteinsU54CA231637 · NCI · DANA-FARBER CANCER INST · PI STEGMAIER, KIMBERLY · 2018 to 2022
$13.2MMetabolic gatekeepers in B-cell malignanciesR35CA197628 · NCI · YALE UNIVERSITY · PI Markus Müschen · 2016 to 2026
$11.7MTargeting Epigenetic Circuits in B-Cell LymphomasR35CA220499 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MELNICK, ARI M. · 2018 to 2024
$7.2MTargeted activation of autoimmune checkpoints in B cell malignanciesR01CA157644 · NCI · YALE UNIVERSITY · PI Markus Müschen · 2011 to 2026
$5.7MTargeting to Epigenetic Modications in ALLR01CA176745 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ARMSTRONG, SCOTT A, QI, JUN · 2012 to 2022
$4.2MFunctional and Mechanistic Study of Histone Crotonylation in Hematological MalignanciesR01CA204639 · NCI · ROCKEFELLER UNIVERSITY · PI ALLIS, CHARLES DAVID, ARMSTRONG, SCOTT A · 2016 to 2020
$3.5MUnderstanding and Targeting Chemotherapy Resistance in Acute Myeloid LeukemiaR01CA198089 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CARROLL, MARTIN · 2015 to 2019
$3.3MECOG-ACRIN INTEGRATED LEUKEMIA TRANSLATIONAL RESEARCH CENTERU10CA180827 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI LEVINE, ROSS L, MELNICK, ARI M. · 2014 to 2018
$3.0MTargeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2024
$2.8MCombinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage LeukemiaR37CA233691 · NCI · MAYO CLINIC ROCHESTER · PI CHEN, CHUN-WEI DAVID · 2019 to 2025
$2.8MPRE-B CELL RECEPTOR SIGNALING IN ACUTE LYMPHOBLASTIC LEUKEMIAR01CA137060 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MÜSCHEN, MARKUS · 2009 to 2016
$2.7MHoward Hughes Medical Institute HHMI-55108547Medical Research Council MC_UU_00016/6Medical Research Council MC_UU_12009/6NCI NIH HHS P01 CA066996NCI NIH HHS R00 CA197498NCI NIH HHS R01 CA137060NCI NIH HHS R01 CA157644NCI NIH HHS R01 CA172558NCI NIH HHS R01 CA176745NCI NIH HHS R01 CA178454NCI NIH HHS R01 CA198089NCI NIH HHS R01 CA204639NCI NIH HHS R01 CA211614NCI NIH HHS R01 CA213138NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA236626NCI NIH HHS R01 CA243386NCI NIH HHS R35 CA197628NCI NIH HHS R35 CA220499NCI NIH HHS R37 CA233691NCI NIH HHS U10 CA180827NCI NIH HHS U54 CA231637
Abstract
Chromosomal rearrangements of the
Indexed as
Gene Expression Regulation, LeukemicAnimalsBiomarkers, TumorCells, CulturedCell SurvivalGene DeletionGene TargetingHumansMiceMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisPromoter Regions, GeneticProto-Oncogene Proteins c-bcl-6BCL6 protein, humanBiomarkers, TumorMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionProto-Oncogene Proteins c-bcl-6B cellsBCL6BIMMLL
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.