Evidence map›Paper›PMID 31395659›Full record

ArticleThe Journal of biological chemistry2019

Inhibition of integrin α

Kui Cui, Nataly P Podolnikova, William Bailey, Eric Szmuc, Eugene A Podrez, Tatiana V Byzova, Valentin P Yakubenko

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
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  8. Review
  9. Article
  10. Article
  11. Article
  12. Inflammatory Microenvironment of Skin Wounds.Frontiers in immunology · 2022
    Review
  13. Article
  14. Frontline Science: The expression of integrin αJournal of leukocyte biology · 2021
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kui CuiDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614.ORCID 0000-0003-2615-4932
Nataly P PodolnikovaCenter for Metabolic and Vascular Biology, School of Life Sciences, Arizona State University, Tempe, Arizona 85281.
William BaileyDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614.
Eric SzmucDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614.
Eugene A PodrezLerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44106.
Tatiana V ByzovaLerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44106.
Valentin P YakubenkoDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 yakubenko@etsu.edu.
East Tennessee State University · USCleveland Clinic Lerner College of Medicine · USArizona State University · US

Funding

Regulation of Integrins in Neovasculature DevelopmentR01HL071625 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2003 to 2021
$7.3M
Pathophysiological Activities of Oxidized PhospholipidsR01HL077213 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2005 to 2018
$4.5M
Platelets in CancerR01HL142772 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2018 to 2021
$2.6M
Role of TLR2 in angiogenesisR01HL145536 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2019 to 2022
$2.6M
The role of β2 integrins in macrophage retention and egress during inflammationR01DK102020 · NIDDK · EAST TENNESSEE STATE UNIVERSITY · PI YAKUBENKO, VALENTIN P · 2014 to 2017
$1.2M
Role of beta2 integrins in macrophage retention and egress during inflammationR56DK102020 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI YAKUBENKO, VALENTIN P · 2014 to 2014
$79k
NHLBI NIH HHS R01 HL071625NHLBI NIH HHS R01 HL077213NHLBI NIH HHS R01 HL142772NHLBI NIH HHS R01 HL145536NIDDK NIH HHS R01 DK102020NIDDK NIH HHS R56 DK102020
6 · The paper itself

Abstract

A critical step in the development of chronic inflammatory diseases is the accumulation of proinflammatory macrophages in the extracellular matrix (ECM) of peripheral tissues. The adhesion receptor integrin α

Indexed as

Cell MovementAnimalsAnti-Inflammatory AgentsCells, CulturedHEK293 CellsHumansIntegrin alpha ChainsMacrophages, PeritonealMiceMice, Inbred C57BLPeptides, CyclicPeritonitisProtein BindingPyrrolesThioglycolates2-(omega-carboxyethyl)pyrroleAnti-Inflammatory AgentsIntegrin alpha ChainsItgad protein, mousePeptides, CyclicPyrrolesThioglycolatesadhesioninflammationintegrinintegrin αDβ2macrophagemigration

Identifiers

PMID31395659
PMCPMC6768641
OpenAlexW2967211009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.