Evidence map›Paper›PMID 31395609›Full record

ReviewCancer research2019

Use of Natural Language Processing to Extract Clinical Cancer Phenotypes from Electronic Medical Records.

Guergana K Savova, Ioana Danciu, Folami Alamudun, Timothy Miller, Chen Lin, Danielle S Bitterman, Georgia Tourassi, Jeremy L Warner

Abstract readReview
In one paragraph

Review in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  18. LCD benchmark: long clinical document benchmark on mortality prediction for language models.Journal of the American Medical Informatics Association : JAMIA · 2025
    Article
  19. Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guergana K SavovaComputational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts. Guergana.Savova@childrens.harvard.edu.
Ioana DanciuOak Ridge National Lab, Knoxville, Tennessee.
Folami AlamudunOak Ridge National Lab, Knoxville, Tennessee.
Timothy MillerComputational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
Chen LinComputational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
Danielle S BittermanHarvard Medical School, Boston, Massachusetts.
Georgia TourassiOak Ridge National Lab, Knoxville, Tennessee.ORCID 0000-0002-9418-9638
Jeremy L WarnerVanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-2851-7242

Funding

Temporal relation discovery for clinical textR01LM010090 · NLM · BOSTON CHILDREN'S HOSPITAL · PI MARTIN, JAMES H., SAVOVA, GUERGANA K. · 2010 to 2022
$7.1M
Cancer Deep Phenotyping from Electronic Medical RecordsU24CA248010 · NCI · BOSTON CHILDREN'S HOSPITAL · PI HARRY S HOCHHEISER, GUERGANA K. SAVOVA · 2020 to 2026
$6.1M
Extended Methods and Software Development for Health NLPR01GM114355 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BETHARD, STEVEN, SAVOVA, GUERGANA K. · 2016 to 2024
$5.0M
Cancer Deep Phenotype Extraction from Electronic Medical RecordsU24CA184407 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAVOVA, GUERGANA K. · 2014 to 2018
$4.4M
Network Analysis for a Data-Driven Approach to Cancer CareU01CA231840 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARNER, JEREMY LYLE · 2018 to 2020
$1.2M
Natural Language Processing Platform for Cancer SurveillanceUG3CA243120 · NCI · BOSTON CHILDREN'S HOSPITAL · PI DURBIN, ERIC B., HOCHHEISER, HARRY S · 2019 to 2020
$872k
NCI NIH HHS U01 CA231840NCI NIH HHS U24 CA184407NCI NIH HHS U24 CA248010NCI NIH HHS UG3 CA243120NIGMS NIH HHS R01 GM114355NLM NIH HHS R01 LM010090
6 · The paper itself

Abstract

Current models for correlating electronic medical records with -omics data largely ignore clinical text, which is an important source of phenotype information for patients with cancer. This data convergence has the potential to reveal new insights about cancer initiation, progression, metastasis, and response to treatment. Insights from this real-world data will catalyze clinical care, research, and regulatory activities. Natural language processing (NLP) methods are needed to extract these rich cancer phenotypes from clinical text. Here, we review the advances of NLP and information extraction methods relevant to oncology based on publications from PubMed as well as NLP and machine learning conference proceedings in the last 3 years. Given the interdisciplinary nature of the fields of oncology and information extraction, this analysis serves as a critical trail marker on the path to higher fidelity oncology phenotypes from real-world data.

Indexed as

Data MiningElectronic Health RecordsHumansMachine LearningMedical OncologyNatural Language ProcessingPhenotype

Identifiers

PMID31395609
PMCPMC7227798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.