Evidence map›Paper›PMID 31395096›Full record

ArticleTrials2019

High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial.

Joshua E McGee, Savanna G Barefoot, Nicole R Gniewek, Patricia M Brophy, Angela Clark, Gabriel S Dubis, Terence E Ryan, Joseph A Houmard, Paul Vos, Thomas D Raedeke and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02892331 (The High Intensity Exercise to Promote Accelerated Improvements in CardiorEspiratory Fitness), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02892331 nacompletednot on this map

The High Intensity Exercise to Promote Accelerated Improvements in CardiorEspiratory Fitness (HI-PACE) Study

TypeinterventionalSponsorEast Carolina UniversityRan2016 to 2021Enrolled52ConditionsObesity, Insulin Resistance, Sedentary LifestyleArmsModerate intensity exercise training (MOD-INT), High Intensity exercise training (HI-INT)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Joshua E McGeeDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA. mcgeej16@students.ecu.edu.ORCID http://orcid.org/0000-0003-0855-1862
Savanna G BarefootDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA.
Nicole R GniewekDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA.
Patricia M BrophyThe East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC, 27858, USA.
Angela ClarkThe East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC, 27858, USA.
Gabriel S DubisDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA.
Terence E RyanDepartment of Physiology, Brody School of Medicine, Greenville, NC, 27858, USA.
Joseph A HoumardDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA.
Paul VosDepartment of Biostatistics, East Carolina University, Greenville, NC, 27858, USA.
Thomas D RaedekeDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA.
Damon L SwiftDepartment of Kinesiology, East Carolina University, 388 Ward Sports Medicine Building, Greenville, NC, 27858, USA.
East Carolina University · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African AmericansR03DK105297 · NIDDK · EAST CAROLINA UNIVERSITY · PI SWIFT, DAMON LEO · 2016 to 2018
$553k
NIA NIH HHS P30 AG028740NIDDK NIH HHS 1R03DK105297-01A1NIDDK NIH HHS R03 DK105297
6 · The paper itself

Abstract

backgroundAfrican Americans have a disproportionate prevalence and incidence of type 2 diabetes compared with Caucasians. Recent evidence indicates that low cardiorespiratory fitness (CRF) level, an independent risk factor for type 2 diabetes, is also more prevalent in African Americans than Caucasians. Numerous studies in Caucasian populations suggest that vigorous exercise intensity may promote greater improvements in CRF and other type 2 diabetes risk factors (e.g., reduction of glucose/insulin levels, pulse wave velocity, and body fat) than moderate intensity. However, current evidence comparing health benefits of different aerobic exercise intensities on type 2 diabetes risk factors in African Americans is negligible. This is clinically important as African Americans have a greater risk for type 2 diabetes and are less likely to meet public health recommendations for physical activity than Caucasians. The purpose of the HI-PACE (High-Intensity exercise to Promote Accelerated improvements in CardiorEspiratory fitness) study is to evaluate whether high-intensity aerobic exercise elicits greater improvements in CRF, insulin action, and arterial stiffness than moderate-intensity exercise in African Americans. METHODS/

designA randomized controlled trial will be performed on overweight and obese (body mass index of 25-45 kg/m DISCUSSION: The anticipated results of the HI-PACE study will provide vital information on the health effects of high-intensity exercise in African Americans. This study will advance health disparity research and has the potential to influence future public health guidelines for physical activity.

trial registrationClinicalTrials.gov identifier: NCT02892331 . Registered on September 8, 2016.

Indexed as

Cardiorespiratory FitnessExerciseRandomized Controlled Trials as TopicAdultAgedBlack or African AmericanHumansMiddle AgedMitochondria, MuscleOutcome Assessment, Health CareOxygen ConsumptionVascular StiffnessAfrican AmericanArterial stiffnessCardiorespiratory fitnessExercise intensityInsulin sensitivityMethodology

Identifiers

PMID31395096
PMCPMC6686537
OpenAlexW2968253970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.