ArticleBMC nephrology2019
Admission serum sodium and potassium levels predict survival among critically ill patients with acute kidney injury: a cohort study.
Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Early Physiological Changes Before Rapid Response Team Activation Differentiate Patients Requiring ICU Transfer: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Predictive Nomogram for Acute Kidney Injury Risk with Vancomycin and Piperacillin Tazobactam in Sepsis Treatment.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Dyskalaemia as a predictor of mortality in sepsis: a retrospective cohort study.BMC infectious diseases · 2025Article
- Electrolyte disorders in the critically ill: a retrospective analysis.Scientific reports · 2025Article
- Severe Vitamin D Deficiency is Associated with Mortality Risk in Critically Ill Patients with Acute Kidney Injury.International journal of general medicine · 2024Article
- Article
- Hypernatremia: Epidemiology and Predictive Role in Emerging and Established Acute Kidney Injury.Journal of clinical medicine research · 2023Review
- Short-term prognostic models for severe acute kidney injury patients receiving prolonged intermittent renal replacement therapy based on machine learning.BMC medical informatics and decision making · 2023Article
- Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study.Journal of nephrology · 2023Article
- Serum potassium in elderly heart failure patients as a predictor of readmission within 1 year.Heart and vessels · 2023Article
- Stratification of Acute Kidney Injury Risk, Disease Severity, and Outcomes by Electrolyte Disturbances.Journal of clinical medicine research · 2023Review
- Increased Serum Sodium at Acute Kidney Injury Onset Predicts In-Hospital Death.Journal of clinical medicine research · 2023Article
- Management for Electrolytes Disturbances during Continuous Renal Replacement Therapy.Electrolyte & blood pressure : E & BP · 2022Review
- Early prognostic impact of serum sodium level among out-of-hospital cardiac arrest patients: a nationwide multicentre observational study in Japan (the JAAM-OHCA registry).Heart and vessels · 2022Observational
- Prediction of acute kidney injury after cardiac surgery: model development using a Chinese electronic health record dataset.Journal of translational medicine · 2022Article
- Microfluidic-based ion-selective thermoplastic electrode array for point-of-care detection of potassium and sodium ions.Mikrochimica acta · 2022Article
- Article
- Association of serum potassium level with early and late mortality in very elderly patients with acute kidney injury.Journal of intensive medicine · 2022Article
- Effect of First Trough Vancomycin Concentration on the Occurrence of AKI in Critically Ill Patients: A Retrospective Study of the MIMIC-IV Database.Frontiers in medicine · 2022Article
- Clinically Distinct Subtypes of Acute Kidney Injury on Hospital Admission Identified by Machine Learning Consensus Clustering.Medical sciences (Basel, Switzerland) · 2021Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients suffering from acute kidney injury (AKI) were associated with impaired sodium and potassium homeostasis. We aimed to investigate how admission serum sodium and potassium independently and jointly modified adverse clinical outcomes among AKI patients.
methodsPatient data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care Database III. Participants were categorized into three groups according to admission serum sodium and potassium, and the cut-off values were determined using smooth curve fitting. The primary outcome was 90-day mortality in the intensive care unit (ICU). Cox proportional hazards models were used to evaluate the prognostic effects of admission serum sodium and potassium levels.
resultsWe included 13,621 ICU patients with AKI (mean age: 65.3 years; males: 55.4%). The middle category of admission serum sodium and potassium levels were 136.0-144.9 mmol/L and 3.7-4.7 mmol/L through fitting smooth curve. In multivariable Cox models, compared with the middle category, patients with hyponatremia or hypernatremia were associated with excess mortality and the HRs and its 95%CIs were 1.38 (1.27, 1.50) and 1.56 (1.36, 1.79), and patients with either hypokalemia or hyperkalemia were associated with excess mortality and the hazard ratios (HRs) and its 95% confidential intervals (95% CIs) were 1.12 (1.02, 1.24) and 1.25 (1.14, 1.36), respectively. Significant interactions were observed between admission serum sodium and potassium levels (P interaction = 0.001), with a higher serum potassium level associated with increased risk of 90-day mortality among patients with hyponatremia, whereas the effects of higher sodium level on prognostic effects of potassium were subtle.
conclusionsAdmission serum sodium and potassium were associated with survival in a U-shaped pattern among patients with AKI, and hyperkalemia predict a worse clinical outcome among patients with hyponatremia.
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