Evidence map›Paper›PMID 31394997›Full record

ArticleJournal of the American Heart Association2019

Low-Cost Fetal Magnetocardiography: A Comparison of Superconducting Quantum Interference Device and Optically Pumped Magnetometers.

Sarah Strand, William Lutter, Janette F Strasburger, Vishal Shah, Oswaldo Baffa, Ronald T Wakai

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03775954 (Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise), which is not on this map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03775954 recruitingnot on this map

Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise

TypeobservationalSponsorMedical College of WisconsinRan2018 to 2028Enrolled30ConditionsHigh Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic PlacentaArmsFetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 128 citations in OpenAlex.

  1. Review
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  6. Fe-Based Nanocrystalline Magnetic Shielding Cylinder with Subfemtotesla-Level Magnetic Noise.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Article
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  11. Review
  12. Review
  13. Article
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  15. Article
  16. The magnetocardiogram.Biophysics reviews · 2024
    Review
  17. Diagnosis and Management of Fetal Arrhythmias in the Current Era.Journal of cardiovascular development and disease · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Sarah StrandDepartment of Medical Physics University of Wisconsin Madison WI.
William LutterDepartment of Medical Physics University of Wisconsin Madison WI.
Janette F StrasburgerDivision of Cardiology Department of Pediatrics Children's Hospital of Wisconsin- Milwaukee Milwaukee WI.
Vishal ShahQuSpin, Inc. Louisville CO.
Oswaldo BaffaDepartment of Physics FFCLRP Ribeirao Preto, University of Sao Paulo Brazil.
Ronald T WakaiDepartment of Medical Physics University of Wisconsin Madison WI.
University of Wisconsin–Madison · USChildren's Hospital of Wisconsin · USQuSpin (United States) · USUniversidade de São Paulo · BR

Funding

Optimized Signal Processing of Fetal MCG R01HL063174 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI WAKAI, RONALD T · 1999 to 2020
$8.4M
High-resolution Non-cryogenic Magnetoencephalography: Systems-Level IntegrationR44MH110288 · NIMH · QUSPIN · PI SHAH, VISHAL K · 2016 to 2022
$5.1M
Low-Cost Fetal MagnetocardiographyR21EB025901 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WAKAI, RONALD T · 2018 to 2019
$415k
Fetal Magnetocardiography Using Non-cryogenic Magnetic Field SensorsR43HL114182 · NHLBI · QUSPIN · PI SHAH, VISHAL K · 2012 to 2012
$197k
NHLBI NIH HHS R01 HL063174NHLBI NIH HHS R43 HL114182NIBIB NIH HHS R21 EB025901NIMH NIH HHS R44 MH110288
6 · The paper itself

Abstract

Background Fetal magnetocardiography (fMCG) is a highly effective technique for evaluation of fetuses with life-threatening arrhythmia, but its dissemination has been constrained by the high cost and complexity of Superconducting Quantum Interference Device (SQUID) instrumentation. Optically pumped magnetometers (OPMs) are a promising new technology that can replace SQUIDs for many applications. This study compares the performance of an fMCG system, utilizing OPMs operating in a person-sized magnetic shield, to that of a conventional fMCG system, utilizing SQUID magnetometers operating in a magnetically shielded room. Methods and Results fMCG recordings were made in 24 subjects using the SQUID system with the mother lying supine in a magnetically shielded room and the OPM system with the mother lying prone in a person-sized, cylindrical shield. Signal-to-noise ratios of the OPM and SQUID recordings were not statistically different and were adequate for diagnostic purposes with both technologies. Although the environmental noise was higher using the small open-ended shield, this was offset by the higher signal amplitude achieved with prone positioning, which reduced the distance between the fetus and sensors and improved patient comfort. In several subjects, fMCG provided a differential diagnosis that was more precise and/or definitive than was possible with echocardiography alone. Conclusions The OPM-based system was portable, improved patient comfort, and performed as well as the SQUID-based system at a small fraction of the cost. Electrophysiological assessment of fetal rhythm is now practical and will have a major impact on management of fetuses with long QT syndrome and other life-threatening arrhythmias.

Indexed as

Arrhythmias, CardiacAtrial FlutterAtrial Premature ComplexesAtrioventricular BlockEchocardiographyFemaleFetal HeartHumansLong QT SyndromeMagnetocardiographyPatient PositioningPregnancyPrenatal DiagnosisProne PositionSignal-To-Noise RatioSupine Positionarrhythmiaelectrophysiologyfetal heartlong QT syndromemagnetocardiography

Identifiers

PMID31394997
PMCPMC6759914
OpenAlexW2967776670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.