Evidence map›Paper›PMID 31394992›Full record

ArticleStroke2019

MiR-126 Mediates Brain Endothelial Cell Exosome Treatment-Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice.

Poornima Venkat, Chengcheng Cui, Michael Chopp, Alex Zacharek, Fengjie Wang, Julie Landschoot-Ward, Yi Shen, Jieli Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 3 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 3 syntheses or guidelines pooled it, 173 citations in OpenAlex.

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  18. Extracellular Vesicles as a Potential Therapy for Stroke.International journal of molecular sciences · 2025
    Review
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  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Poornima VenkatFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Chengcheng CuiFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Michael ChoppFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Alex ZacharekFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Fengjie WangFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Julie Landschoot-WardFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Yi ShenFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Jieli ChenFrom the Department of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.C., M.C., A.Z., F.W., J.L.-W., Y.S., J.C.).
Henry Ford Hospital · USOakland University · US

Funding

Diabetic stroke cardiac dysfunction; treatment with CD133+ExosomesR01HL143432 · NHLBI · HENRY FORD HEALTH SYSTEM · PI CHOPP, MICHAEL · 2018 to 2021
$1.8M
MiR-126/ABCA1 mediates exosome induced neurorestorative effects after stroke in T2DM miceR01NS099030 · NINDS · HENRY FORD HEALTH SYSTEM · PI CHEN, JIELI · 2016 to 2018
$984k
NHLBI NIH HHS R01 HL143432NINDS NIH HHS R01 NS099030
6 · The paper itself

Abstract

Background and Purpose- Stroke patients with type 2 diabetes mellitus (T2DM) exhibit increased vascular and white matter damage and have worse prognosis compared with nondiabetic stroke patients. We investigated the neurorestorative effects of exosomes derived from mouse brain endothelial cells (EC-Exo) as treatment for stroke in T2DM mice and investigated the role of miR-126 in mediating EC-Exo-derived therapeutic benefits in T2DM-stroke mice. Methods- Adult, male BKS.Cg-m+/+Lepr

Indexed as

Diabetes Mellitus, Type 2AnimalsBrainDiabetes Mellitus, ExperimentalEndothelial CellsExosomesMaleMiceMicroRNAsStrokeMicroRNAsMIRN126 microRNA, mouseendothelial cellsexosomesmicestrokevascular remodeling

Identifiers

PMID31394992
PMCPMC6756941
OpenAlexW2969048789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.