Evidence map›Paper›PMID 31394971›Full record

ArticleToxicologic pathology2019

Comparative Incidences and Biological Outcomes for Thymoma in Various Rat Strains in National Toxicology Program Studies.

Rebecca R Moore, Hiroaki Nagai, Rodney A Miller, Jerry F Hardisty, Neil Allison, Keith R Shockley, David E Malarkey

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicologic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rebecca R MooreIntegrated Laboratory Systems, Inc, Research Triangle Park, NC, USA.ORCID 0000-0003-1094-1309
Hiroaki NagaiCellular and Molecular Pathology Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Rodney A MillerExperimental Pathology Laboratories, Inc, Research Triangle Park, NC, USA.
Jerry F HardistyExperimental Pathology Laboratories, Inc, Research Triangle Park, NC, USA.
Neil AllisonExperimental Pathology Laboratories, Inc, Research Triangle Park, NC, USA.
Keith R ShockleyBiostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
David E MalarkeyCellular and Molecular Pathology Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Experimental Pathology Laboratories · USNational Institute of Environmental Health Sciences · USIntegrated Laboratory Systems, Inc. · US

Funding

Toxicologic Pathology Evaluations for the National Toxicology ProgramZIAES103319 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MALARKEY, DAVID · 2016 to 2019
$25.2M
Intramural NIH HHS ZIA ES103319NIEHS NIH HHS HHSN273201500013C
6 · The paper itself

Abstract

Thymomas from 277 Fischer 344/N (F344/N), 10 Sprague Dawley (HSD:Sprague Dawley SD) (SD), 129 Wistar Han [Crl:WI(Han)] (WH), and 4 Wistar Outbred (WO) rats were reviewed from long-term studies in the National Toxicology Program (NTP) database. The incidence of thymomas in F344/N rats was slightly higher in males than in females, while the incidences in SD and WH rats were higher in females than in males. Only male WO rats were used in NTP studies. Of the 277 thymomas in F344/N rats, 235 (84.8%) were benign and 42 (15.2%) malignant, 14 of which exhibited metastasis. Of the 10 thymomas in SD rats, 5 (50%) were benign and 5 (50%) were malignant, one of which exhibited metastasis. Of the 129 thymomas in WH rats, 126 (98%) were benign and 3 (2%) were malignant, 1 with metastasis. Of the 4 thymomas in WO rats, 3 (75%) were benign and 1 (25%) was malignant, with no metastases. Malignant thymomas in F344/N and WH rats showed a propensity to be the cause of death and to result in early mortality, whereas the benign thymomas were associated less often with decreased survival. No occurrences of this neoplasm were reported to be related to exposure to any test articles.

Indexed as

AnimalsFemaleIncidenceMaleRatsRats, Inbred F344Rats, Sprague-DawleyRats, WistarRodent DiseasesThymomaThymus NeoplasmsF344/NNational Toxicology ProgramratSprague DawleythymomathymusWistar Han

Identifiers

PMID31394971
PMCPMC6814546
OpenAlexW2966978222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.