ArticleMolecular pain
Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults.
Abstract read
In one paragraph
Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Chronic Pain in Older Adults: Risk Factors and Prevention.Life (Basel, Switzerland) · 2026Review
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Whole blood DNA methylation signature of epigenetic aging in medication overuse headache.The journal of headache and pain · 2026Article
- Biomarkers and Breakdowns: Neuroinflammatory Drivers Linking Sleep Disorders and Chronic Pain.Biomedicines · 2026Review
- Personality and epigenetic aging: A multi-cohort and multi-clock study.Psychoneuroendocrinology · 2025Article
- The Role of Lifestyle Behaviors in Shaping the Relationship Between Chronic Pain and Epigenetic Age Acceleration: Evidence From NHANES 1998 to 2002.Journal of pain research · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Epigenetic Aging Associations With Psychoneurological Symptoms and Social Functioning in Adults With Sickle Cell Disease.Biological research for nursing · 2024Article
- The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- High-Impact Pain Is Associated With Epigenetic Aging Among Middle-Aged and Older Adults: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Pace of Biological Aging Predicts Nonspecific Chronic Low Back Pain Severity.The journal of pain · 2024Article
- Socioeconomic Status, Knee Pain, and Epigenetic Aging in Community-Dwelling Middle-to-Older Age Adults.The journal of pain · 2024Article
- Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain.Social science & medicine (1982) · 2023Article
- The Epigenetics of Migraine.International journal of molecular sciences · 2023Review
- Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain.Frontiers in aging neuroscience · 2023Article
- Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain.Epigenetics · 2022Article
- Epigenetic aging, knee pain and physical performance in community-dwelling middle-to-older age adults.Experimental gerontology · 2022Article
- Epigenetic age predictors in community-dwelling adults with high impact knee pain.Molecular pain · 2022Article
- Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.The journal of nutrition, health & aging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Yenisel Cruz-Almeida1 Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0065-0236
Puja Sinha5 Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Asha Rani5 Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Zhiguang Huo6 Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, USA.
Roger B Fillingim1 Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Thomas Foster5 Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Funding
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8MEthnic Differences in Responses to Painful StimuliR37AG033906 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2014 to 2023
$12.9MEstrogen and cognition over the lifespanR01AG037984 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C, KUMAR, ASHOK · 2011 to 2022
$3.3Mthe Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2MSignaling cascades and memory deficits during agingR37AG036800 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2010 to 2018
$2.6MUniversity of Florida Resource Center for Minority Aging ResearchP30AG059297 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2018 to 2022
$2.2MUse of viral-vectors for studying effects of chronic inflammation on executive functionR01AG052258 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2016 to 2020
$1.9MMechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8MSystemic inflammation in regulating the onset and progression of brain agingR01AG049711 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2015 to 2019
$1.5MNeuroimaging Age-Related Changes i Pain ModulationK01AG048259 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2015 to 2019
$831kCognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkersK01AA025306 · NIAAA · UNIVERSITY OF FLORIDA · PI PORGES, ERIC · 2017 to 2021
$801kPain and Aging Research Translational InitiativeK07AG046371 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2014 to 2018
$667kNIAAA NIH HHS K01 AA025306NIA NIH HHS K01 AG048259NIA NIH HHS K07 AG046371NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG059297NIA NIH HHS R01 AG037984NIA NIH HHS R01 AG049711NIA NIH HHS R01 AG052258NIA NIH HHS R01 AG059809NIA NIH HHS R37 AG033906NIA NIH HHS R37 AG036800NIA NIH HHS T32 AG049673
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedAged, 80 and overAgingBiomarkersChronic PainDNA MethylationEpigenesis, GeneticFemaleHumansIndependent LivingMaleMiddle AgedPainBiomarkersaging biomarkerBiological agingchronic painepigenetic agingpain biomarker
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.