Evidence map›Paper›PMID 31394807›Full record

ArticleCancers2019

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

Christiaan van Weeghel, Annemijn P A Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A van der Velden, Wilma G M Kroes, Ulrich Pfeffer, Gregorius P M Luyten, Martine J Jager

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Pathological and Molecular Diagnosis of Uveal Melanoma.Diagnostics (Basel, Switzerland) · 2024
    Review
  2. Driver mutations inOncoimmunology · 2023
    Article
  3. Cancers · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Uveal Melanoma.Cancers · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Christiaan van WeeghelDepartment of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Annemijn P A WierengaDepartment of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Mieke VersluisDepartment of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-8885-948X
Thorbald van HallDepartment of Clinical Oncology, LUMC, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9115-558X
Pieter A van der VeldenDepartment of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Wilma G M KroesDepartment of Clinical Genetics, LUMC, 2333 ZA Leiden, The Netherlands.
Ulrich PfefferTumor Epigenetics, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-0872-4671
Gregorius P M LuytenDepartment of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Martine J JagerDepartment of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. m.j.jager@lumc.nl.ORCID 0000-0003-2261-3820
Leiden University Medical Center · NLOspedale Policlinico San Martino · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG17103Compagnia di San Paolo 20067Horizon 2020 667787
6 · The paper itself

Abstract

Inflammation, characterized by high numbers of infiltrating leukocytes and a high HLA Class I expression, is associated with a bad prognosis in uveal melanoma (UM). We wondered whether mutations in

Indexed as

chromosome aberrationsmRNA expressionmutationssurvivaluveal melanoma

Identifiers

PMID31394807
PMCPMC6721447
OpenAlexW2966079957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.