Evidence map›Paper›PMID 31394788›Full record

ReviewNutrients2019

The Role of the Anabolic Properties of Plant- versus Animal-Based Protein Sources in Supporting Muscle Mass Maintenance: A Critical Review.

Insaf Berrazaga, Valérie Micard, Marine Gueugneau, Stéphane Walrand

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07735988 (Effects of Soy Protein and Creatine Supplementation on Body Composition, Acute Muscle Injury, and Biochemical Parameters in Trained Men Performing Resistance Exercise), which is not on this map. Cited by 190 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 10 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07735988 nacompletednot on this mapstarted 2026, after this paper: background citation

Effects of Soy Protein and Creatine Supplementation on Body Composition, Acute Muscle Injury, and Biochemical Parameters in Trained Men Performing Resistance Exercise

TypeinterventionalSponsorYakup Enes ÇamRan2026 to 2026Enrolled54ConditionsHealthy Men Doing Resistance TrainingArmssoy protein, Creatine Monohydrate
3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 10 syntheses or guidelines pooled it, 424 citations in OpenAlex.

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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Insaf BerrazagaUNH, Unité de Nutrition Humaine, CRNH, Université Clermont Auvergne, INRA, Auvergne, 63000 Clermont-Ferrand, France.
Valérie MicardIATE Agropolymer Engineering and Emerging Technologies, Univ. Montpellier, INRA, CIRAD, Montpellier SupAgro, 34060 Montpellier, France.
Marine GueugneauUNH, Unité de Nutrition Humaine, CRNH, Université Clermont Auvergne, INRA, Auvergne, 63000 Clermont-Ferrand, France.
Stéphane WalrandUNH, Unité de Nutrition Humaine, CRNH, Université Clermont Auvergne, INRA, Auvergne, 63000 Clermont-Ferrand, France. stephane.walrand@inra.fr.
Université Clermont Auvergne · FRUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-sourced proteins offer environmental and health benefits, and research increasingly includes them in study formulas. However, plant-based proteins have less of an anabolic effect than animal proteins due to their lower digestibility, lower essential amino acid content (especially leucine), and deficiency in other essential amino acids, such as sulfur amino acids or lysine. Thus, plant amino acids are directed toward oxidation rather than used for muscle protein synthesis. In this review, we evaluate the ability of plant- versus animal-based proteins to help maintain skeletal muscle mass in healthy and especially older people and examine different nutritional strategies for improving the anabolic properties of plant-based proteins. Among these strategies, increasing protein intake has led to a positive acute postprandial muscle protein synthesis response and even positive long-term improvement in lean mass. Increasing the quality of protein intake by improving amino acid composition could also compensate for the lower anabolic potential of plant-based proteins. We evaluated and discussed four nutritional strategies for improving the amino acid composition of plant-based proteins: fortifying plant-based proteins with specific essential amino acids, selective breeding, blending several plant protein sources, and blending plant with animal-based protein sources. These nutritional approaches need to be profoundly examined in older individuals in order to optimize protein intake for this population who require a high-quality food protein intake to mitigate age-related muscle loss.

Indexed as

Anabolic AgentsAdultAgedAged, 80 and overAmino AcidsAnimalsDietary ProteinsDigestionFemaleHumansMaleMiddle AgedMuscle ProteinsMuscle, SkeletalNutritional Physiological PhenomenaPlant ProteinsAmino AcidsAnabolic AgentsDietary ProteinsMuscle ProteinsPlant Proteinsanimal-based proteinscritical reviewmuscle protein synthesisolder peopleplant-based proteinsskeletal muscle

Identifiers

PMID31394788
PMCPMC6723444
OpenAlexW2964651830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.