Evidence map›Paper›PMID 31394776›Full record

ArticleCells2019

HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant.

Hana Rohn, Rafael Tomoya Michita, Sabine Schramm, Sebastian Dolff, Anja Gäckler, Johannes Korth, Falko M Heinemann, Benjamin Wilde, Mirko Trilling, Peter A Horn and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Dimorphism of HLA-E and its Disease Association.International journal of molecular sciences · 2019
    Review
  12. Article
  13. Article
  14. Cellular Immunity Against BK Polyomavirus in Kidney Transplant Recipients: A Comprehensive Review.Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Hana RohnDepartment of Infectious Diseases, West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany. hana.rohn@uk-essen.de.
Rafael Tomoya MichitaInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-3156-9382
Sabine SchrammInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Sebastian DolffDepartment of Infectious Diseases, West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Anja GäcklerDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Johannes KorthDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-4898-0389
Falko M HeinemannInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Benjamin WildeDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Mirko TrillingInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-3659-3541
Peter A HornInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Andreas KribbenDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Oliver WitzkeDepartment of Infectious Diseases, West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Vera RebmannInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-4660-3870
University of Duisburg-Essen · DEUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human leukocyte antigen (HLA)-E is important for the regulation of anti-viral immunity. BK polyomavirus (BKPyV) reactivation after kidney transplant is a serious complication that can result in BKPyV-associated nephropathy (PyVAN) and subsequent allograft loss. To elucidate whether HLA-E polymorphisms influence BKPyV replication and nephropathy, we determined the HLA-E genotype of 278 living donor and recipient pairs. A total of 44 recipients suffered from BKPyV replication, and 11 of these developed PyVAN. Homozygosity of the recipients for the HLA-E*01:01 genotype was associated with the protection against PyVAN after transplant (

Indexed as

Genetic Predisposition to DiseaseKidney TransplantationPolyomavirus InfectionsAdultAgedAllelesFemaleHistocompatibility Antigens Class IHLA-E AntigensHumansKidney DiseasesLiving DonorsMaleMiddle AgedHistocompatibility Antigens Class IHLA-E AntigensBK virushuman leukocyte antigen-Ekidney transplantationnephropathypolyomavirus

Identifiers

PMID31394776
PMCPMC6721664
OpenAlexW2965735596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.