Evidence map›Paper›PMID 31394747›Full record

ArticleMolecules (Basel, Switzerland)2019

Interaction with Blood Proteins of a Ruthenium(II) Nitrofuryl Semicarbazone Complex: Effect on the Antitumoral Activity.

Bruno Demoro, Andreia Bento-Oliveira, Fernanda Marques, João Costa Pessoa, Lucía Otero, Dinorah Gambino, Rodrigo F M de Almeida, Ana Isabel Tomaz

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bruno DemoroCátedra de Química Inorgánica, Facultad de Química, Universidad de la República-UDELAR, 11800 Montevideo, Uruguay.
Andreia Bento-OliveiraCentro de Química Estrutural, Faculdade de Ciências-CQE-FCUL, Universidade de Lisboa, 1749-016 Lisbon, Portugal.
Fernanda MarquesCentro de Ciências Tecnológicas e Nucleares, Instituto Superior Técnico-C2TN-Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, 2686-953 Sacavém, Portugal.
João Costa PessoaCentro de Química Estrutural, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal.ORCID 0000-0002-3978-9964
Lucía OteroCátedra de Química Inorgánica, Facultad de Química, Universidad de la República-UDELAR, 11800 Montevideo, Uruguay.
Dinorah GambinoCátedra de Química Inorgánica, Facultad de Química, Universidad de la República-UDELAR, 11800 Montevideo, Uruguay. dgambino@fq.edu.uy.ORCID 0000-0001-8678-7374
Rodrigo F M de AlmeidaCentro de Química Estrutural, Faculdade de Ciências-CQE-FCUL, Universidade de Lisboa, 1749-016 Lisbon, Portugal.
Ana Isabel TomazCentro de Química Estrutural, Faculdade de Ciências-CQE-FCUL, Universidade de Lisboa, 1749-016 Lisbon, Portugal. isabel.tomaz@ciencias.ulisboa.pt.ORCID 0000-0002-2249-4684
University of Lisbon · PTUniversidad de la República de Uruguay · UY

Funding

CYTED network RIIDFCMEuropean Social Fund Investigador 2013 InitiativeFundação para a Ciência e Tecnologia - F.C.T projects PTDC/QuiQui/101187 /2008, PTDC/BBB-BQB/6071/2014 and IF/01179/2013Fundação para a Ciência e Tecnologia - F.C.T. PEst-OE/QUI/UI0100/2011, PEst-OE/QUI/UI0612/2011, PEst-OE/QUI/UI0536/2011, UID/QUI/00100/2019POPH (Programa Operacional para o Potencial Humano)
6 · The paper itself

Abstract

The steady rise in the cancer burden and grim statistics set a vital need for new therapeutic solutions. Given their high efficiency, metallodrugs are quite appealing in cancer chemotherapy. This work examined the anticancer activity of an anti-trypanosomal ruthenium-based compound bearing the 5-nitrofuryl pharmacophore, [Ru

Indexed as

AlgorithmsAntineoplastic AgentsBlood ProteinsCircular DichroismCoordination ComplexesDrug InteractionsHumansModels, MolecularModels, TheoreticalMolecular StructureProtein BindingRutheniumSemicarbazonesSerum Albumin, HumanAntineoplastic AgentsBlood ProteinsCoordination ComplexesRutheniumSemicarbazonesSerum Albumin, Human5-nitrofurylsemicarbazonecancercircular dichroismconditional binding constantscytotoxicityfluorescencehuman serum albuminhuman serum apo-transferrin.plasma protein bindingruthenium(II)

Identifiers

PMID31394747
PMCPMC6719144
OpenAlexW2966465367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.