ArticlePsychoneuroendocrinology2019
A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulation.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Menstrual Cycle and Athletic Status Interact to Influence Symptoms, Mood, and Cognition in Females.Sports medicine - open · 2025Article
- Impact of Sex and Salivary Dehydroepiandrosterone on the Association Between Testosterone and Emotion Dysregulation.Developmental psychobiology · 2025Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Puberty and NeuroDevelopment in adolescents (PANDA): a study protocol.BMC pediatrics · 2024Article
- Estradiol effects on an emotional interference task in adolescents with current and remitted depression.Hormones and behavior · 2024Article
- Birth, love, and fear: Physiological networks from pregnancy to parenthood.Comprehensive psychoneuroendocrinology · 2022Review
- Article
- On the role of sex steroids in biological functions by classical and non-classical pathways. An update.Frontiers in neuroendocrinology · 2021Review
- fMRI evidence reveals emotional biases in bilingual decision making.Brain structure & function · 2021Article
- Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Non-human primate models have been useful in clarifying estradiol's role in cognitive processing. These animal studies indicate estradiol impacts cognitive processes supported by regions within dorsolateral prefrontal cortex (DLPFC). Although human functional neuroimaging studies have begun to find similar relationships between estradiol in women for some forms of 'cold' cognitive control, to date no studies have examined the relationship between estradiol and DLPFC function in the context of active attempts to regulate one's emotions. Here, we asked whether peripheral 17-beta estradiol levels in adolescent girls in different pubertal developmental stages (age = 14.9 years ± 1.74) were related to engagement of DLPFC regions during the use of a cognitive strategy for regulating emotion known as reappraisal using functional Magnetic Resonance Imaging. Findings indicated that higher estradiol levels predicted greater DLPFC activity during the down-regulation of negative emotion using reappraisal. This is the first report of an association between estradiol level and DLPFC activity during cognitive reappraisal of negative emotion. The study suggests a possibility that estradiol might positively contribute to regulatory function of a cortical system important for emotional experiences.
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Registered trials
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