Evidence map›Paper›PMID 31394082›Full record

ReviewGastroenterology2020

Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults.

Elena M Stoffel, Caitlin C Murphy

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 354 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
354citing papers in PubMed, 9 pooled it
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05234177 recruitingnot on this mapstarted 2022, after this paper: background citation

Tempus CRC Surveillance Study: A Longitudinal Circulating Tumor DNA (ctDNA) Biomarker Profiling Study of Patients With Colorectal Cancer (CRC) Using Comprehensive Next-Generation Sequencing (NGS)Assays

TypeobservationalSponsorTempus AIRan2022 to 2029Enrolled300ConditionsColorectal CancerArmsObservation
NCT07360834 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Predicting Cancer Onset in Lynch Syndrome by Liquid Biopsies

TypeinterventionalSponsorUNICANCERRan2026 to 2030Enrolled2,000ConditionsLynch SyndromeArmsINVITRO DIAGNOSTIC TESTS AND COLONOSCOPY
3 · Its place in the literature

Who cites it

354 citing papers in PubMed, 9 syntheses or guidelines pooled it, 622 citations in OpenAlex.

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294 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Elena M StoffelDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Caitlin C MurphyDivision of Epidemiology, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas; Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: Caitlin.Murphy@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7M
Early life exposures and risk of young-onset colorectal cancerR01CA242558 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MURPHY, CAITLIN C · 2019 to 2023
$1.5M
NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA242558
6 · The paper itself

Abstract

In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in 10 new diagnoses of CRC are now made in individuals 50 years or younger. Patients' risk of CRC has been calculated largely by age and family history, yet 3 of 4 patients with early-onset CRC have no family history of the disease. Rapidly increasing incidence rates in younger people could result from generational differences in diet, environmental exposures, and lifestyle factors. We review epidemiologic trends in CRC, data on genetic and nongenetic risk factors, and new approaches for determining CRC risk. These may identify individuals likely to benefit from early screening and specialized surveillance.

Indexed as

Life StyleAge FactorsAge of OnsetColonic NeoplasmsEarly Detection of CancerHumansIncidenceMass ScreeningPatient SelectionPractice Guidelines as TopicRectal NeoplasmsRisk AssessmentRisk FactorsSurvival AnalysisSurvival RateUnited StatesColorectal CancerEarly-Age OnsetEpidemiologyRisk Factors

Identifiers

PMID31394082
PMCPMC6957715
OpenAlexW2966389029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.