Evidence map›Paper›PMID 31393791›Full record

ArticleEnvironmental health perspectives2019

Exposure–Response Associations of Household Air Pollution and Buccal Cell Telomere Length in Women Using Biomass Stoves.

Sabrina Li, Ming Yang, Ellison Carter, James J Schauer, Xudong Yang, Majid Ezzati, Mark S Goldberg, Jill Baumgartner

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PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sabrina LiInstitute for Health and Social Policy, McGill University, Montreal, Quebec, Canada.
Ming YangCancer Research Center, Shandong University, Jinan, China.
Ellison CarterDepartment of Civil and Environmental Engineering, Colorado State University, Fort Collins, Colorado, USA.
James J SchauerDepartment of Civil and Environmental Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Xudong YangDepartment of Building Science, Tsinghua University, Beijing, China.
Majid EzzatiSchool of Public Health, Imperial College London, London, United Kingdom.
Mark S GoldbergDepartment of Medicine, McGill University Health Center, Montreal, Quebec, Canada.
Jill BaumgartnerInstitute for Health and Social Policy, McGill University, Montreal, Quebec, Canada.

Funding

Medical Research Council MR/L01341X/1
6 · The paper itself

Abstract

backgroundTelomere shortening is associated with early mortality and chronic disease. Recent studies indicate that environmental exposures, including urban and traffic-related air pollution, may shorten telomeres. Associations between exposure to household air pollution from solid fuel stoves and telomere length have not been evaluated.

methodsAmong 137 rural Chinese women using biomass stoves ([Formula: see text] of age), we measured 48-h personal exposures to fine particulate matter [PM [Formula: see text] in aerodynamic diameter ([Formula: see text])] and black carbon and collected oral DNA on up to three occasions over a period of 2.5 y. Relative telomere length (RTL) was quantified using a modified real-time polymerase chain reaction protocol. Mixed effects regression models were used to investigate the exposure–response associations between household air pollution and RTL, adjusting for key sociodemographic, behavioral, and environmental covariates.

resultsWomen's daily exposures to air pollution ranged from [Formula: see text] for [Formula: see text] ([Formula: see text]) and [Formula: see text] for black carbon ([Formula: see text]). Natural cubic spline models indicated a mostly linear association between increased exposure to air pollution and shorter RTL, except at very high concentrations where there were few observations. We thus modeled the linear associations with all observations, excluding the highest 3% and 5% of exposures. In covariate-adjusted models, an interquartile range (IQR) increase in exposure to black carbon ([Formula: see text]) was associated with shorter RTL [all observations: [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]); excluding highest 5% exposures: [Formula: see text] (95% CI: [Formula: see text], [Formula: see text])]. Further adjustment for outdoor temperature brought the estimates closer to zero [all observations: [Formula: see text] (95% CI: [Formula: see text], 0.06); excluding highest 5% exposures: [Formula: see text] (95% CI: [Formula: see text], [Formula: see text])]. Models with [Formula: see text] as the exposure metric followed a similar pattern.

conclusionTelomere shortening, which is a biomarker of biological aging and chronic disease, may be associated with exposure to air pollution in settings where household biomass stoves are commonly used. https://doi.org/10.1289/EHP4041.

Indexed as

AdultAgedAged, 80 and overAir Pollution, IndoorBiomassChinaCookingEnvironmental ExposureFemaleHumansMiddle AgedParticulate MatterReal-Time Polymerase Chain ReactionSootTelomere ShorteningParticulate MatterSoot

Identifiers

PMID31393791
PMCPMC6792380

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.