Evidence map›Paper›PMID 31393790›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Postprandial activation of leukocyte-endothelium interaction by fatty acids in the visceral adipose tissue microcirculation.

Kyle J Preston, Inna Rom, Christine Vrakas, Gavin Landesberg, Zienab Etwebi, Sanae Muraoka, Michael Autieri, Satoru Eguchi, Rosario Scalia

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Trained Immunity and Reactivity of Macrophages and Endothelial Cells.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Review
  8. Vascular Endothelial Cells and Innate Immunity.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kyle J PrestonCardiovascular Research Center and.
Inna RomCardiovascular Research Center and.
Christine VrakasCardiovascular Research Center and.
Gavin LandesbergCardiovascular Research Center and.
Zienab EtwebiCardiovascular Research Center and.
Sanae MuraokaCardiovascular Research Center and.
Michael AutieriDepartment of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Satoru EguchiDepartment of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Rosario ScaliaDepartment of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Temple University · US

Funding

Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Inflammatory Responses of The Visceral Adipose Tissue MicrocirculationR01DK111042 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI EGUCHI, SATORU, SCALIA, ROSARIO G · 2017 to 2020
$2.3M
Mechanism of Hypertensive Vascular Remodeling and End-Organ DamageR01HL133248 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI EGUCHI, SATORU · 2016 to 2019
$1.8M
Integrative Mechanisms of Adipose Tissue Dysfunction In obesityR01DK096521 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI SCALIA, ROSARIO G · 2013 to 2016
$1.4M
NHLBI NIH HHS R01 HL133248NIDDK NIH HHS R01 DK096521NIDDK NIH HHS R01 DK111042NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637
6 · The paper itself

Abstract

High-fat diet (HFD)-induced obesity is associated with accumulation of inflammatory cells predominantly in visceral adipose depots [visceral adipose tissue (VAT)] rather than in subcutaneous ones [subcutaneous adipose tissue (SAT)]. The cellular and molecular mechanisms responsible for this phenotypic difference remain poorly understood. Controversy also exists on the overall impact that adipose tissue inflammation has on metabolic health in diet-induced obesity. The endothelium of the microcirculation regulates both the transport of lipids and the trafficking of leukocytes into organ tissue. We hypothesized that the VAT and SAT microcirculations respond differently to postprandial processing of dietary fat. We also tested whether inhibition of endothelial postprandial responses to high-fat meals (HFMs) preserves metabolic health in chronic obesity. We demonstrate that administration of a single HFM or

Indexed as

MicrocirculationAnimalsBlood GlucoseDiet, High-FatEndotheliumFatty AcidsGlucose Tolerance TestIntra-Abdominal FatLeukocytesMaleMice, Inbred C57BLMice, KnockoutObesityPeroxidasePostprandial PeriodP-SelectinBlood GlucoseFatty AcidsPeroxidaseP-Selectinadipocytefree fatty acidsinflammationinsulin resistance

Identifiers

PMID31393790
PMCPMC6902696
OpenAlexW2967843063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.