Evidence map›Paper›PMID 31393789›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

Slug and Snail have differential effects in directing colonic epithelial wound healing and partially mediate the restitutive effects of butyrate.

Steve D Swain, Heather N Grifka-Walk, Jeannie Gripentrog, Margaret Lehmann, Benjamin Deuling, Brittany Jenkins, Hailey Liss, Nathan Blaseg, Diane Bimczok, Douglas J Kominsky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Steve D SwainDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Heather N Grifka-WalkDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Jeannie GripentrogDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Margaret LehmannDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Benjamin DeulingDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Brittany JenkinsDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Hailey LissDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Nathan BlasegDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Diane BimczokDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Douglas J KominskyDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana.
Montana State University · US

Funding

Tracking and Evaluation CoreU54GM115371 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI RASMUS, STACY M., VOYICH, JOVANKA M · 2016 to 2020
$20.9M
Inflammation-dependent methylation in the mucosaR01DK099452 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KOMINSKY, DOUGLAS J · 2014 to 2017
$1.3M
NIDDK NIH HHS R01 DK099452NIGMS NIH HHS U54 GM115371
6 · The paper itself

Abstract

Restitution of wounds in colonic epithelium is essential in the maintenance of health. Microbial products, such as the short-chain fatty acid butyrate, can have positive effects on wound healing. We used an in vitro model of T84 colonic epithelial cells to determine if the Snail genes Slug (

Indexed as

Adaptor Proteins, Signal TransducingButyratesCell LineColonic DiseasesGene Knockdown TechniquesHumansSignal TransductionSnail Family Transcription FactorsTight Junction ProteinsTrefoil Factor-1Trefoil Factor-3Wound HealingAdaptor Proteins, Signal TransducingButyratesITGB1BP1 protein, humanSNAI1 protein, humanSNAI2 protein, humanSnail Family Transcription FactorsTFF1 protein, humanTFF3 protein, humanTight Junction ProteinsTrefoil Factor-1Trefoil Factor-3butyratecolonepitheliumSlugSnail

Identifiers

PMID31393789
PMCPMC6842986
OpenAlexW2968907038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.