ArticleJournal of dental research2019
Molar Bud-to-Cap Transition Is Proliferation Independent.
Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Asymmetry of sonic hedgehog expression is necessary for early incisor tooth morphogenesis.Development (Cambridge, England) · 2026Article
- ECM-Syndecan-4-FAK signaling is associated with epithelial invagination and buccolingual asymmetry during mandibular molar development.Frontiers in physiology · 2026Article
- Article
- Prespecified dental mesenchymal cells for the making of a tooth.International journal of oral science · 2025Article
- Cap-to-bell stage molar tooth morphogenesis occurs through proliferation-independent sulcus sharpening and condensation-associated tension in the dental papilla.Journal of anatomy · 2025Article
- Profiling and functional characterization of long noncoding RNAs during human tooth development.International journal of oral science · 2025Article
- CACNA1S mutation-associated dental anomalies: A calcium channelopathy.Oral diseases · 2024Article
- Identification of novel candidate genes associated with non-syndromic tooth agenesis in Mongolian families.Clinical oral investigations · 2023Article
- Count Me in, Count Me out: Regulation of the Tooth Number via Three Directional Developmental Patterns.International journal of molecular sciences · 2023Review
- Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022Review
- Developmental influence on evolutionary rates and the origin of placental mammal tooth complexity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space.Journal of developmental biology · 2021Article
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
- Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh.Frontiers in cell and developmental biology · 2021Review
- The involvement of genes related to bile secretion pathway in rat tooth germ development.Journal of molecular histology · 2020Article
- Live Tissue Imaging Sheds Light on Cell Level Events During Ectodermal Organ Development.Frontiers in physiology · 2020Review
- An Essential Requirement forFrontiers in cell and developmental biology · 2020Article
- Action of Actomyosin Contraction WithFrontiers in physiology · 2020Article
- Pointing on the early stages of maxillary bone and tooth development - histological findings.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Tooth germs undergo a series of dynamic morphologic changes through bud, cap, and bell stages, in which odontogenic epithelium continuously extends into the underlying mesenchyme. During the transition from the bud stage to the cap stage, the base of the bud flattens and then bends into a cap shape whose edges are referred to as "cervical loops." Although genetic mechanisms for cap formation have been well described, little is understood about the morphogenetic mechanisms. Computer modeling and cell trajectory tracking have suggested that the epithelial bending is driven purely by differential cell proliferation and adhesion in different parts of the tooth germ. Here, we show that, unexpectedly, inhibition of cell proliferation did not prevent bud-to-cap morphogenesis. We quantified cell shapes and actin and myosin distributions in different parts of the tooth epithelium at the critical stages and found that these are consistent with basal relaxation in the forming cervical loops and basal constriction around enamel knot at the center of the cap. Inhibition of focal adhesion kinase, which is required for basal constriction in other systems, arrested the molar explant morphogenesis at the bud stage. Together, these results show that the bud-to-cap transition is largely proliferation independent, and we propose that it is driven by classic actomyosin-driven cell shape-dependent mechanisms. We discuss how these results can be reconciled with the previous models and data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.