Trial reportTransfusion2019
Full annotation of serum virome in Chinese blood donors with elevated alanine aminotransferase levels.
Trial report in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Novel Viral Sequences in a Patient with Cryptogenic Liver Cirrhosis Revealed by Serum Virome Sequencing.Viruses · 2025Article
- Full annotation of viral metagenomics in different components from Chinese blood donors using next-generation sequencing.Blood transfusion = Trasfusione del sangue · 2024Article
- Unveiling microbial worlds: exploring viral metagenomics among waste pickers at Latin America's largest dumpsite.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Expansion ofViruses · 2023Article
- Review
- Phylogenetic analysis of torque teno virus in Romania: possible evidence of distinct geographical distribution.Archives of virology · 2022Article
- Diversity and Long-Term Dynamics of Human Blood Anelloviruses.Journal of virology · 2022Article
- Within-host quantitation of anellovirus genome complexity from clinical samples.Journal of virological methods · 2022Article
- Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging.Immunity & ageing : I & A · 2022Article
- Blood virosphere in febrile Tanzanian children.Emerging microbes & infections · 2021Article
- Comparative metavirome analysis in polytransfused patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Deep sequencing applied to the analysis of viromes in patients with beta-thalassemia.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- A novel target enrichment strategy in next-generation sequencing through 7-deaza-dGTP-resistant enzymatic digestion.BMC research notes · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundA serum alanine aminotransferase (ALT) test is currently demanded for blood donation in China. One of the major reasons to include such a test is possible etiology of known or unknown hepatotropic viruses. However, this hypothesis has never been examined convincingly. STUDY DESIGN AND
methodsThe study recruited 90 Chinese blood donors that were divided into three groups based on their ALT values. Serum virome from these donors was explored using a metagenomics approach with enhanced sensitivity resolved at single sequencing reads.
resultsAnellovirus and pegivirus C (GBV-C) were detected among these donors. None of them were found solely in donors with abnormal liver enzyme. Anellovirus was highly prevalent (93.3%) and the co-infection with multiple genera (alpha, beta, and gammatorquevirus) were more common in the donors with normal ALT values in comparison to those with elevated ALT (single/double/triple Anellovirus genera, 1/3/24 vs. 7/7/14 or 6/7/13, p = 0.009). For unmapped reads that accounted for 15 ± 14.9% of the data, similarity-based (BLASTN, BLASTP, and HMMER3) and similarity-independent (k-mer frequency) analysis identified several circular rep encoding ssDNA (CRESS-DNA) genomes. Direct PCR testing indicated these genomes were likely reagent contaminants.
conclusionViral etiology is not responsible for elevated ALT levels in Chinese blood donors. The ALT test, if not abandoned, should be adjusted for its cutoff in response to donor shortage in China.
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