ArticleDevelopmental medicine and child neurology2020
Brain structure in children with congenital visual disorders and visual impairment.
Article in Developmental medicine and child neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Functional vision promotes quality of life and socio-emotional functioning in visually impaired children and adolescents.PloS one · 2026Article
- Factors Affecting Visual Function in Children with Cerebral Visual Impairment.Beyoglu eye journal · 2025Article
- Visual Function and Neuropsychological Profiling of Idiopathic Infantile Nystagmus.Brain sciences · 2023Article
- Ocular and cerebral causes of visual impairment in young children and a new scoring system to evaluate visual function.International ophthalmology · 2022Article
- Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia.Frontiers in aging neuroscience · 2022Article
- Visual Neuropsychology in Development: Anatomo-Functional Brain Mechanisms of Action/Perception Binding in Health and Disease.Frontiers in human neuroscience · 2021Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo examine if congenital visual impairment is associated with differences in brain anatomy in children.
methodTen children (8-12y) with congenital disorders of the peripheral visual system with severe visual impairment (SVI; >0.8 logMAR) or mild-to-moderate visual impairment (MVI; 0.6-0.8 logMAR) were compared to 21 typically sighted comparison (TSC) children. Thalamus volume, grey matter density, white matter microstructure, and integrity of visual tracts were investigated in SVI, MVI, and TSC groups with anatomical and diffusion-weighted magnetic resonance imaging.
resultsCompared to the TSC group, the SVI group had lower white matter integrity in tracts of the visual system (optic radiations: SVI 0.35±0.015, TSC 0.39±0.007 [p=0.022]; posterior corpus callosum: SVI 0.37±0.019; TSC 0.42±0.009 [p=0.033]) and lower left thalamus volume (SVI 4.37±0.087; TSC 4.99±0.339 [p=0.015]). Neuroanatomical differences were greater in the SVI group, while no consistent differences between the MVI and TSC group were observed.
interpretationPosterior tracts of the visual system are compromised in children with congenital visual impairment versus those who are typically sighted. The severity of visual input appears to have affected neuroanatomical development as significant reductions were only found in the SVI group. WHAT THIS PAPER ADDS: Severe visual impairment in mid-childhood is associated with reduced integrity of visual pathways and reduced thalamus volume.
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