Evidence map›Paper›PMID 31393585›Full record

ArticlePain medicine (Malden, Mass.)2020

Disagreement and Uncertainty Among Experts About how to Respond to Marijuana Use in Patients on Long-term Opioids for Chronic Pain: Results of a Delphi Study.

Joanna L Starrels, Sarah R Young, Soraya S Azari, William C Becker, E Jennifer Edelman, Jane M Liebschutz, Jamie Pomeranz, Payel Roy, Shalini Saini, Jessica S Merlin

Abstract read
In one paragraph

Article in Pain medicine (Malden, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joanna L StarrelsDivision of General Internal Medicine, Albert Einstein College of Medicine and Montefiore Health System, Bronx, New York.
Sarah R YoungDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama.
Soraya S AzariDivision of General Internal Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California.
William C BeckerDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
E Jennifer EdelmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Jane M LiebschutzDivision of General Internal Medicine, Center for Research on Health Care, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Jamie PomeranzDepartment of Occupational Therapy, University of Florida, Gainesville, Florida.
Payel RoyClinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.
Shalini SainiDepartment of Medicine, Information Technology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jessica S MerlinDivision of General Internal Medicine, Center for Research on Health Care, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Funding

Yale Drug use, Addiction and HIV Research Scholars (DAHRS)K12DA033312 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Patrick O'Connor · 2013 to 2026
$7.2M
Prescription opioid use, misuse, disorders and HIV outcomesR01DA039046 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STARRELS, JOANNA L. · 2015 to 2018
$2.4M
Mentoring Junior Investigators to Tackle the Opioid EpidemicK24DA046309 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STARRELS, JOANNA L. · 2018 to 2023
$876k
Development of a Behavioral Intervention for Chronic Pain in Individuals with HIVK23MH104073 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERLIN, JESSICA S · 2015 to 2018
$732k
NIDA NIH HHS K12 DA033312NIDA NIH HHS K24 DA046309NIDA NIH HHS R01 DA039046NIMH NIH HHS K23 MH104073
6 · The paper itself

Abstract

backgroundMarijuana use is common among patients on long-term opioid therapy (LTOT) for chronic pain, but there is a lack of evidence to guide clinicians' response.

objectiveTo generate expert consensus about responding to marijuana use among patients on LTOT.

designAnalysis from an online Delphi study. SETTING/SUBJECTS: Clinician experts in pain and opioid management across the United States.

methodsParticipants generated management strategies in response to marijuana use without distinction between medical and nonmedical use, then rated the importance of each management strategy from 1 (not at all important) to 9 (extremely important). A priori rules for consensus were established, and disagreement was explored using cases. Thematic analysis of free-text responses examined factors that influenced participants' decision-making.

resultsOf 42 participants, 64% were internal medicine physicians. There was consensus that it is not important to taper opioids as an initial response to marijuana use. There was disagreement about the importance of tapering opioids if there is a pattern of repeated marijuana use without clinical suspicion for a cannabis use disorder (CUD) and consensus that tapering is of uncertain importance if there is suspicion for CUD. Three themes influenced experts' perceptions of the importance of tapering: 1) benefits and harms of marijuana for the individual patient, 2) a spectrum of belief about the overall riskiness of marijuana use, and 3) variable state laws or practice policies.

conclusionsExperts disagree and are uncertain about the importance of opioid tapering for patients with marijuana use. Experts were influenced by patient factors, provider beliefs, and marijuana policy, highlighting the need for further research.

Indexed as

Marijuana UsePractice Patterns, Physicians'Analgesics, OpioidChronic PainDelphi TechniqueHumansPain ManagementAnalgesics, OpioidChronic PainDelphi StudyMarijuanaOpioids

Identifiers

PMID31393585
PMCPMC8204879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.