ArticleThe Journal of clinical endocrinology and metabolism2019
Lavender Products Associated With Premature Thelarche and Prepubertal Gynecomastia: Case Reports and Endocrine-Disrupting Chemical Activities.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Systematic evidence mapping informs a class-based approach to assessing personal care products and pubertal timing.Environment international · 2023Pooled it
- A proposed evaluation of new approach methodologies for dermal toxicity assessment of botanicals.Pharmaceutical biology · 2026Review
- Essential Oils and Their Multifunctional Activities Against Pseudomonas aeruginosa: Current Evidence and Perspectives.MicrobiologyOpen · 2026Review
- Compendial Perspectives on Botanical Identity Testing.Journal of natural products · 2026Review
- Medicinal Plants for Acne Vulgaris: An Evidence-Based Review of Treatments Promoted by Social Media.Journal of cosmetic dermatology · 2026Review
- Toxic Alerts of Endocrine Disruption Revealed by Explainable Artificial Intelligence.Environment & health (Washington, D.C.) · 2025Article
- Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial.Frontiers in pharmacology · 2025Article
- Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review.Toxics · 2024Review
- Premature Thelarche: An Updated Review.Current pediatric reviews · 2024Review
- Critical assessment of the endocrine potential of Linalool and Linalyl acetate: proactive testing strategy assessing estrogenic and androgenic activity of Lavender oil main components.Archives of toxicology · 2024Article
- Are Prepubertal Gynaecomastia and Premature Thelarche Linked to Topical Lavender and Tea Tree Oil Use?TouchREVIEWS in endocrinology · 2023Review
- Letter to the Editor Regarding “Effect of Propolis on Precocious Puberty in Female Rats” - Does Propolis Induce Thelarche and Gynecomastia in Prepubertal Children?Journal of clinical research in pediatric endocrinology · 2023Article
- Comparative Studies on the Anti-Inflammatory and Apoptotic Activities of Four Greek Essential Oils: Involvement in the Regulation of NF-κΒ and Steroid Receptor Signaling.Life (Basel, Switzerland) · 2023Article
- A Status Review on Health-Promoting Properties and Global Regulation of Essential Oils.Molecules (Basel, Switzerland) · 2023Review
- Drosophila melanogaster as a model for studies related to the toxicity of lavender, ginger and copaiba essential oils.PloS one · 2023Article
- Cocktail Effect of Endocrine Disrupting Chemicals: Application to Chlorpyrifos in Lavender Essential Oils.International journal of environmental research and public health · 2022Article
- Endocrine Disrupting Chemicals' Effects in Children: What We Know and What We Need to Learn?International journal of molecular sciences · 2022Review
- Evaluation of Placental Toxicity of Five Essential Oils and Their Potential Endocrine-Disrupting Effects.Current issues in molecular biology · 2022Article
- Prevalence of endocrine disorders among children exposed to Lavender Essential Oil and Tea Tree Essential Oils.International journal of pediatrics & adolescent medicine · 2022Article
- Alternative Flavored Inhalable Products-A New Respiratory Hazard?Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
contextPrevious case reports associated prepubertal gynecomastia with lavender-containing fragrances, but there appear to be no reports of premature thelarche.
objectiveTo add to a case series about lavender-fragranced product use and breast growth in children and to measure endocrine-disrupting chemical activity of essential oil components. DESIGN, SETTING, AND PATIENTS: Patients experiencing premature thelarche or prepubertal gynecomastia with continuous exposure to lavender-fragranced products were evaluated in the pediatric endocrinology departments of two institutions. Mechanistic in vitro experiments using eight components of lavender and other essential oils were performed at National Institute of Environmental Health Sciences.
main outcome measuresCase reports and in vitro estrogen and androgen receptor gene expression activities in human cell lines with essential oils.
resultsThree prepubertal girls and one boy with clinical evidence of estrogenic action and a history of continuous exposure to lavender-containing fragrances were studied. Breast growth dissipated in all patients with discontinuation of the fragranced products. Some of the components tested elicited estrogenic and antiandrogenic properties of varying degrees.
conclusionWe report cases of premature thelarche that resolved upon cessation of lavender-containing fragrance exposure commonly used in Hispanic communities. The precise developmental basis for such conditions could be multifactorial. In vitro demonstration of estrogenic and antiandrogenic properties of essential oil components suggests essential oils in these cases could be considered a possible source and supports a possible link with idiopathic prepubertal breast development. Whether the level of lavender oil estrogenic potency is sufficient to cause these effects is unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.