ArticleCritical care medicine2019
The ED-SED Study: A Multicenter, Prospective Cohort Study of Practice Patterns and Clinical Outcomes Associated With Emergency Department SEDation for Mechanically Ventilated Patients.
Article in Critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed.
- Post-intubation sedation in the emergency department: A scoping review.The American journal of emergency medicine · 2026Article
- Management of Mechanical Ventilation in Emergency Medicine: A Scoping Review.Journal of the American College of Emergency Physicians open · 2026Review
- Sedation practices in patients intubated in the emergency department compared with those in patients in the intensive care unit.Critical care science · 2025Article
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- Article
- Noninvasive respiratory support in the emergency department: Controversies and state-of-the-art recommendations.Journal of the American College of Emergency Physicians open · 2024Review
- Article
- Observational
- The Profile of Early Sedation Depth and Clinical Outcomes of Mechanically Ventilated Patients in Korea.Journal of Korean medical science · 2023Article
- A dual-center cohort study on the association between early deep sedation and clinical outcomes in mechanically ventilated patients during the COVID-19 pandemic: The COVID-SED study.Critical care (London, England) · 2022Article
- A Dual-Center Cohort Study on The Association Between Early Deep Sedation and Clinical Outcomes in Mechanically Ventilated Patients During the COVID-19 Pandemic: the COVID-SED Study.Research square · 2022Article
- Factors Associated With Deep Sedation Practice in Mechanically Ventilated Patients: AFrontiers in medicine · 2022Article
- The AIR-SED Study: A Multicenter Cohort Study of SEDation Practices, Deep Sedation, and Coma Among Mechanically Ventilated AIR Transport Patients.Critical care explorations · 2021Article
- Variability in sedation assessment among intubated patients in the emergency department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- A Target for Increased Mortality Risk in Critically Ill Patients: The Concept of Perpetuity.Journal of clinical medicine · 2021Article
- The ED-AWARENESS Study: A Prospective, Observational Cohort Study of Awareness With Paralysis in Mechanically Ventilated Patients Admitted From the Emergency Department.Annals of emergency medicine · 2021Observational
- Impact of Providing a Tape Measure on the Provision of Lung-protective Ventilation.The western journal of emergency medicine · 2021Article
- Tools Are Needed to Promote Sedation Practices for Mechanically Ventilated Patients.Frontiers in medicine · 2021Article
- Article
- Initial emergency department mechanical ventilation strategies for COVID-19 hypoxemic respiratory failure and ARDS.The American journal of emergency medicine · 2020Review
Corrections and comments
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Authors and funding
30 authors.
Funding
Abstract
objectivesTo characterize emergency department sedation practices in mechanically ventilated patients, and test the hypothesis that deep sedation in the emergency department is associated with worse outcomes.
designMulticenter, prospective cohort study.
settingThe emergency department and ICUs of 15 medical centers. PATIENTS: Mechanically ventilated adult emergency department patients.
interventionsNone. MEASUREMENTS AND MAIN
resultsAll data involving sedation (medications, monitoring) were recorded. Deep sedation was defined as Richmond Agitation-Sedation Scale of -3 to -5 or Sedation-Agitation Scale of 2 or 1. A total of 324 patients were studied. Emergency department deep sedation was observed in 171 patients (52.8%), and was associated with a higher frequency of deep sedation in the ICU on day 1 (53.8% vs 20.3%; p < 0.001) and day 2 (33.3% vs 16.9%; p = 0.001), when compared to light sedation. Mean (SD) ventilator-free days were 18.1 (10.8) in the emergency department deep sedation group compared to 20.0 (9.8) in the light sedation group (mean difference, 1.9; 95% CI, -0.40 to 4.13). Similar results according to emergency department sedation depth existed for ICU-free days (mean difference, 1.6; 95% CI, -0.54 to 3.83) and hospital-free days (mean difference, 2.3; 95% CI, 0.26-4.32). Mortality was 21.1% in the deep sedation group and 17.0% in the light sedation group (between-group difference, 4.1%; odds ratio, 1.30; 0.74-2.28). The occurrence rate of acute brain dysfunction (delirium and coma) was 68.4% in the deep sedation group and 55.6% in the light sedation group (between-group difference, 12.8%; odds ratio, 1.73; 1.10-2.73).
conclusionsEarly deep sedation in the emergency department is common, carries over into the ICU, and may be associated with worse outcomes. Sedation practice in the emergency department and its association with clinical outcomes is in need of further investigation.
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