Evidence map›Paper›PMID 31393087›Full record

ArticlePediatric pulmonology2019

Long-term morbidity of respiratory viral infections during chemotherapy in children with leukaemia.

Beryl Lin, Brendan Kennedy, Jamie McBride, Luciano Dalla-Pozza, Toby Trahair, Geoffrey McCowage, Emma Coward, Leanne Plush, Paul D Robinson, Kate Hardaker and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Beryl LinFaculty of Medicine, University of New South Wales, Sydney, Australia.ORCID 0000-0002-2299-9770
Brendan KennedyDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia.
Jamie McBrideDepartment of Respiratory Medicine, Sydney Children's Hospital, Sydney, Australia.
Luciano Dalla-PozzaCancer Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.
Toby TrahairFaculty of Medicine, University of New South Wales, Sydney, Australia.
Geoffrey McCowageCancer Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.
Emma CowardDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia.
Leanne PlushDepartment of Respiratory Medicine, Sydney Children's Hospital, Sydney, Australia.
Paul D RobinsonDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia.
Kate HardakerDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia.
John WidgerFaculty of Medicine, University of New South Wales, Sydney, Australia.
Anthea NgCancer Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.
Adam JaffeDepartment of Respiratory Medicine, Sydney Children's Hospital, Sydney, Australia.
Hiran SelvaduraiDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia.
Children's Hospital at Westmead · AUSydney Children's Hospital · AUThe University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory viruses are a common cause of infection in immunosuppressed children undergoing cancer therapy. Pulmonary sequelae have been documented following respiratory viral infections (RVIs) in hematopoietic stem cell transplant (HSCT) recipients; however potential late effects in children undergoing nonmyeloablative chemotherapy have not been investigated.

aimTo evaluate the long-term pulmonary morbidity of respiratory viral infections during chemotherapy in children with acute lymphoblastic leukemia (ALL).

methodsChildhood ALL survivors, aged 7 to 18 years, greater than 6 months posttreatment were recruited. Exclusion criteria included HSCT or proven bacterial/fungal respiratory infection during treatment. Subjects were classified into "viral" or "control" groups according to retrospective medical records that documented the presence of laboratory-proven RVIs during chemotherapy. Symptom questionnaires (Liverpool, ISAAC) and lung function testing (spirometry, plethysmography, diffusing capacity, forced oscillation technique to ATS/ERS standards) were then performed cross-sectionally at the time of recruitment.

resultsFifty-four patients (31 viral, 23 control) were recruited: median (range) age 11.2 (7.2-18.1) years, and at 4.9 (0.5-13) years posttherapy. Abnormalities were detected in 17 (31%) individuals (8 viral, 9 control), with the most common being DLCO impairment (3 viral, 4 control) and reduced respiratory reactance at 5 Hz (5 viral, 6 control). Children with RVIs during chemotherapy reported more current respiratory symptoms, particularly wheeze (odds ratio [OR], 3.0; 95% confidence interval [CI]: 0.9-10.0; P = .09) and cough (OR, 2.7; 95% CI: 0.8-9.5; P = .11). No differences in lung function tests were observed between the two groups.

conclusionsOur study found children with RVIs during chemotherapy developed more long-term respiratory symptoms than controls; however, differences did not reach statistical significance. No differences in static lung function were found between the two groups. Overall, pulmonary abnormalities and/or significant ongoing respiratory symptoms were detected in nearly a third of ALL survivors treated without HSCT. Larger, prospective studies are warranted to evaluate the etiology and clinical significance of these findings.

Indexed as

AdolescentAntineoplastic AgentsChildCross-Sectional StudiesFemaleHumansMalePrecursor Cell Lymphoblastic Leukemia-LymphomaRespiratory Function TestsRespiratory Tract InfectionsRetrospective StudiesVirus DiseasesAntineoplastic Agentscancer survivorschildneoplasmsrespiratory function testsrespiratory traction infections

Identifiers

PMID31393087
PMCPMC7167615
OpenAlexW2968834192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.