Evidence map›Paper›PMID 31392920›Full record

ReviewNeurodegenerative disease management2019

Diagnostic evaluation and monitoring of patients with posterior cortical atrophy.

Bonnie Wong, Diane E Lucente, Julie MacLean, Jaya Padmanabhan, Megan Quimby, Katherine D Brandt, Deepti Putcha, Janet Sherman, Matthew P Frosch, Scott McGinnis and 1 more

Abstract readReview
In one paragraph

Review in Neurodegenerative disease management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pisa Syndrome Secondary to Drugs: A Scope Review.Geriatrics (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Diagnosis and Management of Posterior Cortical Atrophy.Current treatment options in neurology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Recent update on the heterogeneity of the Alzheimer's disease spectrum.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bonnie WongPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Diane E LucentePosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Julie MacLeanDepartment of Physical & Occupational Therapy, Massachusetts General Hospital, Boston, MA 02114, USA.
Jaya PadmanabhanPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Megan QuimbyPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Katherine D BrandtPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Deepti PutchaPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Janet ShermanPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Matthew P FroschDepartment of Pathology, Division of Neuropathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Scott McGinnisPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Bradford C DickersonPosterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Funding

THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Imaging tau, amyloid, and neurodegeneration in PPAR01DC014296 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, JOHNSON, KEITH A. · 2016 to 2020
$4.3M
Tau Imaging in Atypical ADR21AG051987 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, MCGINNIS, SCOTT MICHAEL · 2016 to 2017
$470k
NIA NIH HHS P30 AG062421NIA NIH HHS P50 AG005134NIA NIH HHS R21 AG051987NIDCD NIH HHS R01 DC014296
6 · The paper itself

Abstract

Posterior cortical atrophy (PCA) is a progressive neurocognitive syndrome, most commonly associated with the loss of complex visuospatial functions. Diagnosis is challenging, and international consensus classification and nomenclature for PCA subtypes have only recently been reached. Presently, no established treatments exist. Efforts to develop treatments are hampered by the lack of standardized methods to monitor illness progression. Although measures developed from work with Alzheimer's disease and other dementias provide a foundation for diagnosing and monitoring progression, PCA presents unique challenges for clinicians counseling patients and families on clinical status and prognosis, and experts designing clinical trials of interventions. Here, we review issues facing PCA clinical research and care, summarize our approach to diagnosis and monitoring of disease progression, and outline ideas for developing tools for these purposes.

Indexed as

AgedAge of OnsetAlzheimer DiseaseAtrophyCognition DisordersCognitive DysfunctionDementiaDiagnosis, DifferentialDisease ManagementDisease ProgressionExecutive FunctionFemaleGenetic Predisposition to DiseaseHumansLanguage DisordersMaleAlzheimer’s diseasebiomarkerscerebral cortexclinical trialsMRIneuropsychologypositron emission tomographyposterior cortical atrophy

Identifiers

PMID31392920
PMCPMC6949516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.