Evidence map›Paper›PMID 31392848›Full record

ArticleAnnals of clinical and translational neurology2019

A robotic neck brace to characterize head-neck motion and muscle electromyography in subjects with amyotrophic lateral sclerosis.

Haohan Zhang, Biing-Chwen Chang, Jinsy Andrews, Hiroshi Mitsumoto, Sunil Agrawal

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Evaluating Range of Motion of Two Prominent Neck Support Devices for Daily Activities.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  3. A Novel Single-Loop Mechanism for Neck Rehabilitation.Biomimetics (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haohan ZhangDepartment of Mechanical Engineering, Columbia University, New York, New York, 10027.ORCID 0000-0002-4827-4217
Biing-Chwen ChangDepartment of Mechanical Engineering, Columbia University, New York, New York, 10027.
Jinsy AndrewsThe Eleanor and Lou Gehrig ALS Center, Department of Neurology, Columbia University, New York, New York, 10032.
Hiroshi MitsumotoThe Eleanor and Lou Gehrig ALS Center, Department of Neurology, Columbia University, New York, New York, 10032.
Sunil AgrawalDepartment of Mechanical Engineering, Columbia University, New York, New York, 10027.ORCID 0000-0002-4008-1437
Columbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis paper presents the first study where a dynamic neck brace was used to characterize the head motion of ALS patients while concurrently recording the surface electromyography (EMG) of the neck muscles.

methodsEleven ALS patients and 10 age-matched healthy controls consented and participated in an experiment. Each participant was asked to perform three single-plane motions of the head-neck that included flexion-extension in the sagittal plane, lateral bending in the coronal plane, and axial rotation in the transverse plane. Each motion was performed in a cycle and was repeated five times at self-selected speeds.

resultsDuring single-plane flexion-extension under gravity, compared to healthy peers, ALS patients showed a shorter duration to reach the maximum flexion and an earlier EMG onset in the neck extensors starting from the neutral. The brace measures in activation of the neck muscles in ALS patients were well correlated with clinically measured scores, such as the ALSFRS-r and the FVC. The activation duration of sternocleidomastoid, used to rotate the head, correlated well with the ALSFRS-r and FVC in ALS patients during axial rotation.

interpretationThe ability to synchronously activate a pair of muscles to execute single-plane motions in ALS patients seems to have been compromised due to the disease and potentially results in head drop. The neck brace measures can be adapted in the clinic to complement self-reporting in ALS patients and used to assess the head drop and progress of the disease.

Indexed as

BracesRoboticsAdultAgedAmyotrophic Lateral SclerosisElectromyographyFemaleHead MovementsHumansMaleMiddle AgedMuscle StrengthNeck MusclesRange of Motion, Articular

Identifiers

PMID31392848
PMCPMC6764623
OpenAlexW2969091556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.