Evidence map›Paper›PMID 31392697›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Validation of Calibration Parameters for Trapped Ion Mobility Spectrometry.

Cameron N Naylor, Tobias Reinecke, Mark E Ridgeway, Melvin A Park, Brian H Clowers

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cameron N NaylorDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA.
Tobias ReineckeDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA.
Mark E RidgewayBruker Daltonics Inc., Billerica, MA, 01821, USA.
Melvin A ParkBruker Daltonics Inc., Billerica, MA, 01821, USA.
Brian H ClowersDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA. brian.clowers@wsu.edu.ORCID http://orcid.org/0000-0002-5809-9379

Funding

Defense Threat Reduction Agency HDTRA1-14-1-0023Division of Chemistry CHE-1506672
6 · The paper itself

Abstract

Using contemporary theory for ion mobility spectrometry (IMS), gas-phase ion mobilities within a trapped ion mobility-mass spectrometer (TIMS) are not easily deduced using first principle equations due to non-linear pressure changes and consequently variations in E/N. It is for this reason that prior literature values have traditionally been used for TIMS calibration. Additionally, given that verified mobility standards currently do not exist and the that the exact conditions used to measure reported literature values may not always represent the environment within the TIMS, a direct approach to validating the behavior of the TIMS system is warranted. A calibration procedure is presented where an ambient pressure, ambient temperature, two-gate, printed circuit board drift-tube IMS (PCBIMS) is coupled to the front of a TIMS allowing reduced mobilities to be directly measured on the same instrument as the TIMS. These measured mobilities were used to evaluate the TIMS calibration procedure which correlates reduced mobility and TIMS elution voltages with literature values. When using the measured PCBIMS-reduced mobilities of tetraalkyl ammonium salts and tune mix for TIMS calibration of the alkyltrimethyl ammonium salts, the percent error is less than 1% as compared with using the reported literature K

Indexed as

Drift-tube ion mobility spectrometryIon mobility calibrationMass spectrometryTrapped ion mobility spectrometry

Identifiers

PMID31392697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.