ArticleJournal of assisted reproduction and genetics2019
Effects of a carrier's sex and age on the segregation patterns of the trivalent of Robertsonian translocations.
Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical analysis of the effect of embryonic outcomes in carriers of chromosomal translocations from different parental sources: A retrospective cohort study of 178 couples.The journal of obstetrics and gynaecology research · 2025Article
- Chromosome segregation of human nonhomologous Robertsonian translocations: insights from preimplantation genetic testing.European journal of human genetics : EJHG · 2025Article
- Article
- Single Nucleotide Polymorphism array analysis for fetuses from balanced translocation carriers at the second trimester.Heliyon · 2024Article
- A working model for the formation of Robertsonian chromosomes.Journal of cell science · 2024Article
- A Retrospective Analysis of Robertsonian Translocations from a Single Center in China.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Effects of chromosomal translocation characteristics on fertilization and blastocyst development - a retrospective cohort study.BMC medical genomics · 2023Article
- Retrospective Analysis of Meiotic Segregation Pattern and Reproductive Outcomes in Blastocysts from Robertsonian Preimplantation Genetic Testing Cycles.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The effect of carrier characteristics and female age on preimplantation genetic testing results of blastocysts from Robertsonian translocation carriers.Journal of assisted reproduction and genetics · 2023Article
- Exploration of the interchromosomal effects in preimplantation genetic testing for structural rearrangements based on next-generation sequencing.Molecular genetics & genomic medicine · 2022Article
- Risk Factors Affecting Alternate Segregation in Blastocysts From Preimplantation Genetic Testing Cycles of Autosomal Reciprocal Translocations.Frontiers in genetics · 2022Article
- Meiotic Heterogeneity of Trivalent Structure and Interchromosomal Effect in Blastocysts With Robertsonian Translocations.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the effects of a carrier's sex and age on the segregation patterns of the trivalent of Robertsonian translocations.
methodsThis retrospective study was designed to analyze the segregation patterns of the trivalent and euploidy rates of blastocysts. Data were collected from 154 couples with Robertsonian translocation (77 with a female carrier and 77 with a male carrier). Embryos were diagnosed via array comparative genomic hybridization between January 2013 and July 2017. The segregation patterns of the trivalent of 604 blastocysts were analyzed according to the carrier's sex and age.
resultsThe proportion of alternate segregation was significantly higher (82.9% vs. 55.2%) in the male carriers than in the female carriers of Robertsonian translocation, and the proportion of adjacent segregation was significantly lower (16.8% vs. 42.6%), with no difference in 3:0 segregation. The segregation patterns were similar in same-sex carriers when analyzed according to the type of translocation. The carrier's age had no influence on the segregation patterns of the trivalent.
conclusionsThe proportions of the trivalent's meiotic segregation pattern differ significantly according to the carrier's sex in Robertsonian translocations and are independent of the carrier's age. A significantly higher proportion of alternate segregation for normal or balanced chromosome contents was observed in the blastocysts of the male carriers than in those of the female carriers.
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