Evidence map›Paper›PMID 31392597›Full record

ArticleJournal of neuro-oncology2019

Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms.

Mohammed Albatany, Valeriy G Ostapchenko, Susan Meakin, Robert Bartha

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Article
  9. The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021
    Review
  10. Article
  11. Targeting the pH Paradigm at the Bedside: A Practical Approach.International journal of molecular sciences · 2020
    Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohammed AlbatanyCentre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, 1151 Richmond Street, London, ON, N65B7, Canada.ORCID http://orcid.org/0000-0002-6785-097X
Valeriy G OstapchenkoCentre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, 1151 Richmond Street, London, ON, N65B7, Canada.
Susan MeakinDepartment of Biochemistry, The University of Western Ontario, London, ON, N65B7, Canada.
Robert BarthaCentre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, 1151 Richmond Street, London, ON, N65B7, Canada. rbartha@robarts.ca.
Western University · CA

Funding

Ontario Institute of Cancer Research (OICR) Smarter Imaging Program Grant Number 00807
6 · The paper itself

Abstract

introductionNon-invasively distinguishing aggressive from non-aggressive brain tumors is an important clinical challenge. Intracellular pH (pH

methodsUsing a 9.4 T MRI scanner, CEST spectra were acquired sensitive to pH

resultsTwo hours after combination drug injection there was a significant 0.1 ± 0.03 increase in tumor AACID value corresponding to a 0.4 decrease in pH

conclusionsThe combined drug treatment with glucose produced a large acute CEST MRI contrast indicating tumor acidification, which could be used to help localize brain cancer and monitor tumor response to chemotherapy.

Indexed as

AnimalsAntioxidantsApoptosisBrainBrain NeoplasmsCell ProliferationDichloroacetic AcidFemaleGlioblastomaHumansHydrogen-Ion ConcentrationHypoglycemic AgentsMiceMice, NudeQuercetinTopiramateAntioxidantsDichloroacetic AcidHypoglycemic AgentsQuercetinTopiramateApoptosisBrain cancerCESTGlioblastoma multiforme (GBM)MRIpH

Identifiers

PMID31392597
OpenAlexW2965258642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.