Evidence map›Paper›PMID 31392564›Full record

ArticleJournal of muscle research and cell motility2020

Skeletal muscle cell transplantation: models and methods.

Amber L Mueller, Robert J Bloch

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of muscle research and cell motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  8. Available In Vitro Models for Human Satellite Cells from Skeletal Muscle.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Review
  11. Therapeutic Strategies Targeting DUX4 in FSHD.Journal of clinical medicine · 2020
    Review
  12. Review
  13. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amber L MuellerDepartment of Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA.
Robert J BlochDepartment of Physiology, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA. rbloch@umaryland.edu.ORCID 0000-0002-4933-3469
University of Maryland, Baltimore · US

Funding

A Novel Xenograft Model of FSHDR21NS086902 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BLOCH, ROBERT J · 2014 to 2015
$781k
Modeling FSHD by Xenografting Human Myogenic Precursor Cells into MiceF31AR070621 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI MUELLER, AMBER LEVELL · 2017 to 2018
$71k
Friends of FSH Research A Xenograft Model of FSHD...FSH Society FSHS-22016-04FSH Society (US) 61848 (subcontract from Dr. Peter Jones)NIAMS NIH HHS 1 F31 AR070621NIAMS NIH HHS F31 AR070621NINDS NIH HHS 1 R21 NS-086902NINDS NIH HHS R21 NS086902
6 · The paper itself

Abstract

Xenografts of skeletal muscle are used to study muscle repair and regeneration, mechanisms of muscular dystrophies, and potential cell therapies for musculoskeletal disorders. Typically, xenografting involves using an immunodeficient host that is pre-injured to create a niche for human cell engraftment. Cell type and method of delivery to muscle depend on the specific application, but can include myoblasts, satellite cells, induced pluripotent stem cells, mesangioblasts, immortalized muscle precursor cells, and other multipotent cell lines delivered locally or systemically. Some studies follow cell engraftment with interventions to enhance cell proliferation, migration, and differentiation into mature muscle fibers. Recently, several advances in xenografting human-derived muscle cells have been applied to study and treat Duchenne muscular dystrophy and Facioscapulohumeral muscular dystrophy. Here, we review the vast array of techniques available to aid researchers in designing future experiments aimed at creating robust muscle xenografts in rodent hosts.

Indexed as

AnimalsCell TransplantationHumansMiceMice, Inbred NODMice, SCIDMuscle, SkeletalFSHDMuscular dystrophyMyoblast transfer therapySatellite cellTransplantationXenograft

Identifiers

PMID31392564
OpenAlexW2965097340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.