Evidence map›Paper›PMID 31392467›Full record

ArticleVirchows Archiv : an international journal of pathology2020

Comparison of PD-L1 expression between paired cytologic and histologic specimens from non-small cell lung cancer patients.

C Kuempers, L I S van der Linde, M Reischl, W Vogel, F Stellmacher, M Reck, D Heigener, K F Rabe, J Kirfel, S Perner and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Article
  6. PD-L1 and beyond: Immuno-oncology in cytopathology.Cytopathology : official journal of the British Society for Clinical Cytology · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

C KuempersInstitute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160 (Building 50), 23538, Luebeck, Germany.
L I S van der LindeCytologic Laboratory, LungenClinic Grosshansdorf, Wöhrendamm 80, 22927, Großhansdorf, Germany.
M ReischlInstitute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
W VogelInstitute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160 (Building 50), 23538, Luebeck, Germany.
F StellmacherPathology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
M ReckCytologic Laboratory, LungenClinic Grosshansdorf, Wöhrendamm 80, 22927, Großhansdorf, Germany.
D HeigenerHelios Klinikum Schleswig, Schleswig, Germany.
K F RabeCytologic Laboratory, LungenClinic Grosshansdorf, Wöhrendamm 80, 22927, Großhansdorf, Germany.
J KirfelInstitute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160 (Building 50), 23538, Luebeck, Germany.
S PernerInstitute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160 (Building 50), 23538, Luebeck, Germany. sven.perner@uksh.de.
L WelkerCytologic Laboratory, LungenClinic Grosshansdorf, Wöhrendamm 80, 22927, Großhansdorf, Germany. l.welker@gmx.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expression of programmed death ligand 1 assessed on histologic samples is a confirmed predictive biomarker for anti-PD-1 immunotherapy, but its evaluation is not approved for immunocytochemistry. We investigated if PD-L1 expression shows comparable results on paired cytologic and histologic tumor specimens and interobserver variability. Percentage of PD-L1-positive tumor cells of 247 paired samples of non-small cell lung cancer was evaluated by three independent investigators. Samples were compared on the basis of the continuous values and also categorized with the tumor proportion score (TPS). Concordance was defined if continuous values were both within a deviation of 10% and if categorized values were identically grouped. Interobserver variability was assessed by the standard deviation of the mean. Based on continuous values between paired samples, perfect concordance rate was approximately 53%. With categorization of PD-L1 expression based on TPS, category was identical in 74.1%. However, defining the continuous values of PD-L1 expression between paired samples within a deviation of 10% as concordant, concordance rate was 82%. Interobserver variability was significantly higher in evaluation of cytologic specimens. Evaluation of PD-L1 expression in paired histologic and cytologic tumor specimens shows comparable results if a deviation of 10% between the values is tolerated. Interobserver variability demonstrates a much more challenging interpretation of PD-L1 expression for cytologic samples.

Indexed as

AdultAgedAged, 80 and overB7-H1 AntigenBiomarkers, TumorCarcinoma, Non-Small-Cell LungFemaleHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedObserver VariationB7-H1 AntigenBiomarkers, TumorCD274 protein, humanCytologicExpressionHistologicNSCLCPaired samplesProgrammed death ligand 1 (PD-L1)

Identifiers

PMID31392467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.