ReviewCurrent genetics2020
Rejuvenation of ribosomal RNA gene repeats at the nuclear pore.
Review in Current genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ribosomal RNA genes (rDNA) exist as tandem repeats in eukaryotes and are, therefore, highly unstable. Each rDNA unit includes a replication fork barrier site to avoid collisions between DNA replication forks and transcriptional machinery. However, because of this barrier, DNA double-strand breaks are induced at a relatively high frequency. If damage is repaired by the homologous recombination in rDNAs, it may result in frequent copy number changes and the production of extrachromosomal ribosomal DNA circles, both of which are closely linked to the regulation of lifespan. Here, we review recent progress in elucidating a multi-layered repair process of rDNA that occurs in the nucleolus, nucleoplasm and nuclear pores. Binding to nuclear pores appears to be the final strategy for repairing any remaining damage to the rDNA. Here, we propose the possible contribution of nuclear pores to the asymmetric distribution of damaged rDNA between mother and daughter cells as well as its possible impact on aging/rejuvenation.
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Registered trials
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