Evidence map›Paper›PMID 31392332›Full record

ArticleOpen forum infectious diseases2019

Detection and Concentration of Plasma Aflatoxin is Associated with Detection of Oncogenic Human Papillomavirus in Kenyan Women.

Jianjun Zhang, Omenge Orang'o, Philip Tonui, Yan Tong, Titus Maina, Stephen Kiptoo, Katpen Muthoka, John Groopman, Joshua Smith, Erin Madeen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
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  7. Review
  8. Article
  9. Review
  10. Evaluation of acute and chronic exposure to aflatoxin BEnvironmental science and pollution research international · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Jianjun ZhangDepartment of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Omenge Orang'oDepartment of Reproductive Health, Moi University, Eldoret, Kenya.
Philip TonuiDepartment of Reproductive Health, Moi University, Eldoret, Kenya.
Yan TongDepartment of Biostatistics, Indiana University School of Medicine and Fairbanks School of Public Health, Indianapolis, IN, USA.
Titus MainaDepartment of Molecular Biology, Maseno University, Kenya.
Stephen KiptooAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Katpen MuthokaAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
John GroopmanDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Joshua SmithDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Erin MadeenDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Aaron ErmelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Patrick LoehrerDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Darron R BrownDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Johns Hopkins University · USAMPATH · KEIndiana University School of MedicineMoi University · KEIndiana University – Purdue University Indianapolis · USMaseno University · KE

Funding

Translational Biology CoreU54CA190151 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROWN, DARRON R, LOEHRER, PATRICK J. · 2014 to 2019
$3.8M
Brown/Moi Training Program for the Prevention of HIV related Cervical CancerD43TW011317 · FIC · BROWN UNIVERSITY · PI CU-UVIN, SUSAN · 2019 to 2023
$1.6M
FIC NIH HHS D43 TW011317NCI NIH HHS U54 CA190151
6 · The paper itself

Abstract

backgroundCervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, as only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a co-factor.

methodsDemographics, behavioral data, plasma, and cervical swabs were collected from 88 HIV-uninfected Kenyan women without cervical dysplasia. HPV detection was compared between women with or without plasma AFB1-lys and evaluated in relation to AFB1-lys concentration.

resultsValid HPV testing results were available for 86 women (mean age 34.0 years); 49 women (57.0%) had AFB1-lys detected and 37 (43.0%) had none. AFB1-lys detection was not associated with age, being married, having more than secondary school education, home ownership, living at a walking distance to health care ≥60 minutes, number of lifetime sex partners, or age of first sex. AFB1-lys detection and plasma concentrations were associated with detection of oncogenic HPV types.

conclusionsAFB1-lys-positivity and higher plasma AFB1-lys concentrations were associated with higher risk of oncogenic HPV detection in cervical samples from Kenya women. Further studies are needed to determine if aflatoxin interacts with HPV in a synergistic manner to increase the risk of cervical cancer.

Identifiers

PMID31392332
PMCPMC6736060
OpenAlexW2967599089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.