Evidence map›Paper›PMID 31392268›Full record

ArticleScience advances2019

Treating ischemia via recruitment of antigen-specific T cells.

Brian J Kwee, Bo Ri Seo, Alexander J Najibi, Aileen W Li, Ting-Yu Shih, Des White, David J Mooney

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Antigen-conjugated scaffolds enable sustained delivery of antigen and enrichment of antigen-specific T-cells.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Self-assembling Peptide Hydrogels Facilitate Vascularization in Two-Component Scaffolds.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2021
    Article
  16. Review
  17. Review
  18. T Cells in Fibrosis and Fibrotic Diseases.Frontiers in immunology · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brian J KweeJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-4426-1363
Bo Ri SeoJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-0871-015X
Alexander J NajibiJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-7761-392X
Aileen W LiJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-1056-5932
Ting-Yu ShihJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Des WhiteWyss Institute Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
David J MooneyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-6299-1194
Harvard University · USInspire Institute · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELSR01DE013349 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOONEY, DAVID J · 2000 to 2022
$9.3M
NCI NIH HHS P30 CA006516NIDCR NIH HHS R01 DE013349
6 · The paper itself

Abstract

Ischemic diseases are a leading cause of mortality and can result in autoamputation of lower limbs. We explored the hypothesis that implantation of an antigen-releasing scaffold, in animals previously vaccinated with the same antigen, can concentrate T

Indexed as

Adjuvants, ImmunologicAllergensAluminumAnimalsAntigensFemaleHumansIschemiaMiceMuscle, SkeletalMyofibrilsNecrosisOvalbuminTh2 CellsT-LymphocytesVaccinesAdjuvants, ImmunologicAllergensAluminumAntigensOvalbuminVaccines

Identifiers

PMID31392268
PMCPMC6669016
OpenAlexW2965284764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.