Evidence map›Paper›PMID 31392247›Full record

ArticleMovement disorders clinical practice2019

The BRadykinesia Akinesia INcoordination (BRAIN) Tap Test: Capturing the Sequence Effect.

Hasan Hasan, Maggie Burrows, Dilan S Athauda, Bruce Hellman, Ben James, Thomas Warner, Thomas Foltynie, Gavin Giovannoni, Andrew J Lees, Alastair J Noyce

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06174948 (The Use of the CUE1/CUE1+ Device in People With Idiopathic Parkinson's Disease and Related Disorders), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06174948 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Use of the CUE1/CUE1+ Device in People With Idiopathic Parkinson's Disease and Related Disorders: A Feasibility Study

TypeinterventionalSponsorQueen Mary University of LondonRan2024 to 2025Enrolled70ConditionsParkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Different Types of Tremor Including Essential Tremor, DystoniaArmsCUE1 non-invasive device, CUE1+ device active vs sham CUE1+ device
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  15. Clinical Motor Coordination Tests in Adult Neurology: A Scoping Review.Physiotherapy Canada. Physiotherapie Canada · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Hasan HasanInstitute of Neurology Queen Square University College London, London UK.ORCID https://orcid.org/0000-0001-9843-9297
Maggie BurrowsDepartment of Clinical and Movement Neurosciences Institute of Neurology Queen Square, University College London, London UK.
Dilan S AthaudaDepartment of Clinical and Movement Neurosciences Institute of Neurology Queen Square, University College London, London UK.
Bruce HellmanuMotif Ltd London UK.
Ben JamesuMotif Ltd London UK.
Thomas WarnerDepartment of Clinical and Movement Neurosciences Institute of Neurology Queen Square, University College London, London UK.
Thomas FoltynieDepartment of Clinical and Movement Neurosciences Institute of Neurology Queen Square, University College London, London UK.ORCID https://orcid.org/0000-0003-0752-1813
Gavin GiovannoniBlizard Institute Queen Mary University London, Barts and the London School of Medicine and Dentistry London UK.
Andrew J LeesDepartment of Clinical and Movement Neurosciences Institute of Neurology Queen Square, University College London, London UK.
Alastair J NoyceDepartment of Clinical and Movement Neurosciences Institute of Neurology Queen Square, University College London, London UK.
Queen Mary University of London · GB

Funding

Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Parkinson's UK F-1201Parkinson's UK G-1606
6 · The paper itself

Abstract

backgroundThe BRadykinesia Akinesia INcoordination (BRAIN) tap test is an online keyboard tapping task that has been previously validated to assess upper limb motor function in Parkinson's disease (PD).

objectivesTo develop a new parameter that detects a sequence effect and to reliably distinguish between PD patients

methodsThe BRAIN test scores in 61 patients with PD and 93 healthy controls were compared. A range of established parameters captured number and accuracy of alternate taps. The new velocity score recorded the intertap speed. Decrement in the velocity score was used as a marker for the sequence effect. In the validation phase, 19 PD patients and 19 controls were tested using different hardware including mobile devices.

resultsQuantified slopes from the velocity score demonstrated bradykinesia (sequence effect) in PD patients (slope cut-off -0.002) with 58% sensitivity and 81% specificity (discovery phase of the study) and 65% sensitivity and 88% specificity (validation phase). All BRAIN test parameters differentiated between

conclusionThe BRAIN tap test is a simple, user-friendly, and free-to-use tool for the assessment of upper limb motor dysfunction in PD, which now includes a measure of bradykinesia.

Indexed as

ambulatory monitoringdigital healthhypokinesiaobjective measuresParkinson's disease

Identifiers

PMID31392247
PMCPMC6660282
OpenAlexW2952420900

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.