ReviewAmerican journal of cancer research2019
Long noncoding RNAs, emerging and versatile regulators of tumor-induced angiogenesis.
Review in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 78 citations in OpenAlex.
- Heartbreakers and healers: RNA rebels in cardio-oncology.Seminars in cancer biology · 2026Review
- Noncoding RNAs: A Novel Frontier in Liver Cancer Research and Therapy: Implications for Precision Oncology.Sub-cellular biochemistry · 2026Review
- Recent Insights into the Angioregulatory Role of Long Non-coding RNAs and Circular RNAs in Gliomas: From Signaling Pathways to Clinical Aspects.Current medicinal chemistry · 2025Review
- Investigating the Role of HOTAIR and MALAT1 Long Noncoding RNAs and Their Relations With Bone Marrow Environment in Acute Myeloid Leukemia Subtypes: Biomarkers and Treatment Response.Advances in hematology · 2025Review
- Anti-angiogenesis in colorectal cancer therapy.Cancer science · 2024Review
- LncRNAs in oncogenic microenvironment: from threat to therapy.Frontiers in cell and developmental biology · 2024Review
- Exosomal SOX21-AS1 Regulates EREG by Sponging miR-451a and Promotes the Malignancy of Pancreatic Ductal Adenocarcinoma.Journal of Cancer · 2024Article
- Downregulated antisense lncRNAAmerican journal of cancer research · 2024Article
- CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers.The Yale journal of biology and medicine · 2023Review
- Discovery of long non-coding RNAs in the liver fluke, Fasciola hepatica.PLoS neglected tropical diseases · 2023Article
- Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets.Cancers · 2023Review
- Article
- Long non-coding RNAs in bone metastasis: progresses and perspectives as potential diagnostic and prognostic biomarkers.Frontiers in endocrinology · 2023Review
- Tumor Cell-derived Extracellular Vesicles in Modulating Phenotypes and Immune Functions of Macrophages: Mechanisms and Therapeutic Applications.Journal of Cancer · 2023Review
- Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors.Bioengineered · 2022Review
- Tumor microenvironment pathways: Cross regulation in breast cancer metastasis.Genes & diseases · 2022Review
- LncRNAs and the Angiogenic Switch in Cancer: Clinical Significance and Therapeutic Opportunities.Genes · 2022Review
- MIR22HG Aggravates Oxygen-Glucose Deprivation and Reoxygenation-Induced Cardiomyocyte Injury through the miR-9-3p/SH2B3 Axis.Cardiovascular therapeutics · 2022Article
- Article
- Expression of Dickkopf-1 and Twist2 in Cervical Squamous Cell Carcinoma and Their Correlation with Vasculogenic Mimicry.Journal of healthcare engineering · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis is an essential step in maintaining tumor growth and facilitating metastasis. The regulatory mechanisms of tumor-induced angiogenesis are extremely complicated, and include sophisticated crosstalk between tumors and surrounding microenvironment cells, oncogenic signaling pathway activation and aberrant expression of angiogenesis-related genes. Recently, emerging evidence demonstrated that long noncoding RNAs (lncRNAs) play crucial roles in angiogenesis. However, there are lack of reports to review the progression in this scientific field. Here, we focus on and summarize the latest findings of lncRNA in angiogenesis in various cancers. Firstly, we introduced how lncRNAs in tumor cells to modulate the cellular signaling axis, interact with proteins and serve as competitive endogenous RNAs (ceRNAs) to alter target gene expression, by which induce endothelial cell to form capillaries. Then, we recapitulated the essential functions of lncRNA in endothelial cells, and how lncRNAs in tumor-associated macrophages to mediate angiogenesis. Next, the angiogenesis mechanism of tumor-derived lncRNAs via exosomes were collectively described. At last, the effects of lncRNAs on vasculogenic mimicry were summarized, which showed that malignant tumor cells acquire dedifferentiated and endothelial properties to form vessel-like structures by themselves. This review provides new insights into the complexity of angiogenesis, and suggests that lncRNAs may become promising biomarkers and targets for enhancing the efficacy of anti-angiogenesis therapy in cancer.
Indexed as
Identifiers
31392075PMC6682713W2990730477What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.