ArticleJournal of gastrointestinal oncology2019
Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management.
Article in Journal of gastrointestinal oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.The British journal of surgery · 2024Guideline
- Adenomatous Polyposis Coli Gene Polyposis-Related Syndromes.The American journal of gastroenterology · 2026Review
- Case Report: Delayed intra-abdominal hemorrhage in a patient with a duodenal stump tumor after Billroth II gastrectomy.Frontiers in oncology · 2026Article
- Upper GI polyposis and cancer in FAP: diagnosis, surveillance and treatment.Familial cancer · 2025Review
- Worldwide Impact of Upper Gastrointestinal Disease in Familial Adenomatous Polyposis.Diagnostics (Basel, Switzerland) · 2025Review
- Hereditary Colorectal Cancer Syndromes: Small Bowel Cancer Risk and Endoscopic Surveillance Strategies.Diagnostics (Basel, Switzerland) · 2025Review
- Outcomes following duodenectomy in patients with familial adenomatous polyposis.Endoscopy international open · 2024Article
- Progression of duodenal neoplasia to advanced adenoma in patients with familial adenomatous polyposis.Hereditary cancer in clinical practice · 2023Article
- Endoscopic and chemopreventive management of familial adenomatous polyposis syndrome.Familial cancer · 2023Review
- PANCREATIC SOLID-PSEUDOPAPILLARY NEOPLASM IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023Article
- Review
- Image-enhanced endoscopy for real-time differentiation between hyperplastic and fundic gland polyps in the stomach.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Prevalence and endoscopic treatment outcomes of upper gastrointestinal neoplasms in familial adenomatous polyposis.Surgical endoscopy · 2022Article
- Prevalence of Gastroduodenal Polyps in Children With Familial Adenomatous Polyposis.Journal of the Canadian Association of Gastroenterology · 2021Article
- Implications of Bariatric Surgery in Patients with Familial Adenomatous Polyposis Requiring Proctocolectomy with Ileal Pouch Anal Anastomosis.Obesity surgery · 2020Article
- Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis.Molecular genetics & genomic medicine · 2020Article
- Impact of enteroscopy on diagnosis and management of small bowel tumors.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Long-term clinical outcomes and follow-up status in Japanese patients with familial adenomatous polyposis after radical surgery: a descriptive, retrospective cohort study from a single institute.International journal of colorectal disease · 2020Article
- Improved outcomes in Familial Adenomatous polyposis management. Results achieved in a single center over a 40-year period.Clinics (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the prevalence of upper gastrointestinal (GI) polyps in familial adenomatous polyposis (FAP), and to discuss current therapeutic recommendations.
methodsClinical, endoscopic, histological and treatment data were retrieved from charts of 102 patients [1958-2016]. Duodenal adenomatosis was classified according to Spigelman stages.
resultsthis series comprised 59 women (57.8%) and 43 men (42.1%) with a median age of 32.3 years. Patients underwent 184 endoscopic procedures, the first at a median age of 35.9 years (range, 13-75 years). Fundic gastric polyps (n=31; 30.4%) prevailed in the stomach. While only 5 adenomas were found in the stomach, 33 patients (32.4%) presented duodenal ones. Advanced lesions (n=13; 12.7%) were detected in the stomach (n=2) and duodenum (n=11). During follow-up, Spigelman stages improved in 6 (12.2%) patients, remained unchanged in 25 (51.0%) and worsened in 18 (36.7%). Carcinomas were diagnosed in the stomach and duodenum (4 lesions each, 3.9%), at median ages of 50.2 and 55.0 years, respectively. Advanced lesions and carcinomas were managed through local or surgical resections. Severe complications occurred in only 2 patients (one death). Enteroscopy in 21 patients revealed jejunal adenomas in 12, 11 of whom also presented duodenal adenomas.
conclusionsThere is a high prevalence of upper GI adenomas and cancer in FAP. There were diagnosed fundic gastric polyps (30.4%), duodenal (32.4%) and jejunal adenomas (11.8%), respectively. One third of duodenal polyps progressed slowly throughout the study. The rates of advanced gastroduodenal lesions (12.7%) and cancer (7.8%) raise the need for continuous surveillance during follow-up.
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