ArticleVirus evolution2019
Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot.
Article in Virus evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Bluetongue virus: current perspectives on characterisation and the need to formalise nomenclature in an era of rapidly evolving technology.The Journal of general virology · 2026Review
- Detection, genetic characterization and reassortment analysis of Tribeč virus.Archives of virology · 2026Article
- Optimized library preparation, sequencing, and data analysis protocols for the generation of orbivirus consensus sequences.BMC genomics · 2026Article
- Phylogenetic insights into the transmission dynamics of arthropod-borne viruses.Nature reviews. Genetics · 2026Review
- National Seroprevalence and Risk Factors of Bluetongue Virus in Domestic Ruminants of Peru.Transboundary and emerging diseases · 2025Article
- Analyses and Insights into Genetic Reassortment and Natural Selection as Key Drivers ofViruses · 2024Article
- In Situ Hybridization (RNAscope) Detection of Bluetongue Virus Serotypes 10 and 17 in Experimentally Co-InfectedPathogens (Basel, Switzerland) · 2023Article
- Widespread Reassortment Contributes to Antigenic Shift in Bluetongue Viruses from South Africa.Viruses · 2023Article
- Genome-Wide Reassortment Analysis of Influenza A H7N9 Viruses Circulating in China during 2013-2019.Viruses · 2022Article
- Genetic and phylogenetic characterization of polycistronic dsRNA segment-10 of bluetongue virus isolates from India between 1985 and 2011.Virus genes · 2021Article
- Article
- Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.Viruses · 2021Article
- Article
- The Genome Segments of Bluetongue Virus Differ in Copy Number in a Host-Specific Manner.Journal of virology · 2020Article
- Deciphering type-specific neutralizing antibodies to bluetongue virus in goats of Andaman and Nicobar Islands, India.Tropical animal health and production · 2020Article
- Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8.Microorganisms · 2020Article
- Article
- Ecological Dynamics Impacting Bluetongue Virus Transmission in North America.Frontiers in veterinary science · 2020Review
- Prospects of Next-Generation Vaccines for Bluetongue.Frontiers in veterinary science · 2019Review
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14 authors.
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Abstract
For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes, this process and its effect on transmission dynamics remain poorly understood. Here, we assessed the consequences of reassortment for selection on viral diversity through time using bluetongue virus (BTV), a segmented arbovirus that is the causative agent of a major disease of ruminants. We analysed ninety-two BTV genomes isolated across four decades from India, where BTV diversity, and thus opportunities for reassortment, are among the highest in the world. Our results point to frequent reassortment and segment turnover, some of which appear to be driven by selective sweeps and serial hitchhiking. Particularly, we found evidence for a recent selective sweep affecting segment 5 and its encoded NS1 protein that has allowed a single variant to essentially invade the full range of BTV genomic backgrounds and serotypes currently circulating in India. In contrast, diversifying selection was found to play an important role in maintaining genetic diversity in genes encoding outer surface proteins involved in virus interactions (VP2 and VP5, encoded by segments 2 and 6, respectively). Our results support the role of reassortment in driving rapid phenotypic change in segmented viruses and generate testable hypotheses for
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