ArticleVirus evolution2019
Changes on the viral capsid surface during the evolution of porcine circovirus type 2 (PCV2) from 2009 till 2018 may lead to a better receptor binding.
Article in Virus evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Molecular Surveillance and Evolutionary Dynamics of Porcine Circovirus Types 2 and 3 in China, 2022-2025.Transboundary and emerging diseases · 2026Article
- Article
- Knowledge gaps in research and control of porcine circovirus 2 (PCV2) infections.BMC veterinary research · 2025Review
- Detection of PCV2d in pig industry of the Iberian Peninsula.Veterinary research communications · 2025Article
- Efficacy of a new ready-to-use vaccine against PCV-2d andVeterinarni medicina · 2025Article
- Host-driven evolution of PCV2: insights into genetic diversity and adaptation.Frontiers in immunology · 2025Article
- Protein embeddings reveal a continuous molecular landscape of host adaptation in waterfowl parvoviruses.Frontiers in bioinformatics · 2025Article
- Molecular evolution and genotype shift of Porcine circoviruses type 2 in Vietnam.Veterinary research communications · 2024Article
- Molecular characterization of canine circovirus based on the Capsid gene in Thailand.BMC veterinary research · 2024Article
- Molecular basis for the different PCV2 susceptibility of T-lymphoblasts in Landrace and Piétrain pigs.Veterinary research · 2024Article
- Both recombinantHeliyon · 2023Article
- Functional and evolutionary analysis of host Synaptogyrin-2 in porcine circovirus type 2 susceptibility.PLoS genetics · 2023Article
- Revisiting Porcine Circovirus Infection: Recent Insights and Its Significance in the Piggery Sector.Vaccines · 2023Review
- Isolation and genetic analysis of Porcine circovirus 2 in southern India evidences high circulation of Porcine circovirus 2d genotype.Molecular biology reports · 2022Article
- Survey of porcine circovirus type 2 and parvovirus in swine breeding herds of Colombia.Veterinary medicine and science · 2022Article
- Molecular genotypic analysis of porcine circovirus type 2 reveals the predominance of PCV2d in Vietnam (2018-2020) and the association between PCV2h, the recombinant forms, and Vietnamese vaccines.Archives of virology · 2022Article
- Rapid detection of porcine circovirus type 2 by a red latex microsphere immunochromatographic strip.Applied microbiology and biotechnology · 2022Article
- Article
- Current knowledge on epidemiology and evolution of novel porcine circovirus 4.Veterinary research · 2022Review
- Genetic Diversity of Porcine Circovirus Types 2 and 3 in Wild Boar in Italy.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases (PCVAD). Three major PCV2 genotypes (PCV2a, PCV2b, and PCV2d) have been identified globally. Despite their worldwide distribution, the prevalence and genetic evolution of PCV2 in Belgium has not previously been determined. In this study, 319 samples from animals suffering from diseases likely to be associated with PCV2 were collected from 2009 to 2018 and analysed by virus titration. The overall prevalence of PCV2 in PCVAD-suspected cases was 15.7 per cent (50/319). The phylogenetic analysis demonstrated that at least three genotypes (PCV2a, PCV2b, and PCV2d) circulated in Belgium from 2009 till 2018, and that PCV2 evolved from PCV2a to PCV2b and from PCV2d-1 to PCV2d-2. Sequence comparison among the forty-three PCV2 isolates showed that they had 89.7-100 per cent nucleotide-sequence and 88.5-100 per cent amino-acid-sequence identities. Three amino acid sites were under positive selection. Three-dimensional analysis of genotype-specific amino acids revealed that most of the mutations were on the outside of the cap protein with a few conserved mutations present on the inner side. Mutations toward more basic amino acids were found on the upper and tail parts of two connecting capsid proteins which form one big contact region, most probably involved in receptor binding. The lower part was relatively conserved. This polarity change together with the formation of an extruding part drive the virus to a more efficient GAG receptor binding. Taken together, these results showed a genotype shift from PCV2a to PCV2b and later on from PCV2d-1 to PCV2d-2, and a PCV2 evolution toward a better receptor binding capacity.
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