Evidence map›Paper›PMID 31391942›Full record

ArticleTherapeutic advances in infectious disease

Antimicrobial susceptibility patterns of organisms causing secondary abdominal infections in patients with perforated abdominal viscus.

Praveen Kumar-M, Nusrat Shafiq, Pradeep Kumar, Ashish Gupta, Samir Malhotra, Naveen M, Vikas Gautam, Pallab Ray, Rajesh Gupta, Vikas Gupta and 4 more

Abstract read
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Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Praveen Kumar-MDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Nusrat ShafiqDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Room No. 4017, Research Block B, Chandigarh 160012, India.ORCID https://orcid.org/0000-0001-7053-003X
Pradeep KumarDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ashish GuptaDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Samir MalhotraDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Naveen MDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Vikas GautamDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Pallab RayDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Rajesh GuptaDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Vikas GuptaDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Thakur Deen YadavDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
G R VermaDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Rajinder SinghDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Gurpreet SinghDepartment of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSecondary peritonitis, following intestinal perforation, constitutes a significant proportion of cases admitted as a surgical emergency and has a mortality rate of 6-21% worldwide. As a part of an antimicrobial stewardship program, we noted considerable variation among the choice of empirical regimens among such cases. Hence, we conducted a prospective study to generate the evidence for a rational empiric regimen for patients with secondary peritonitis following intestinal perforation.

methodsThe study included a complete follow up of 77 cases of secondary peritonitis admitted during a 12 month period. The intraoperative fluid (peritoneal) sample of the patient was sent for culture and sensitivity pattern analysis.

resultsThe sites of perforation as seen in decreasing order were lower gastrointestinal (GI) (50.6%), upper GI (36.4%), and unclassified (13%). The most common organism found in the intraoperative fluid was

conclusionBased on our prospective study, piperacillin-tazobactam or imipenem should be used empirically in patients presenting with complicated intra-abdominal infections secondary to perforated viscus, especially if they have sepsis or septic shock.

Indexed as

antimicrobial stewardshipempirical regimenperforation peritonitisperitonitissurgical prophylaxis

Identifiers

PMID31391942
PMCPMC6669836

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.