ReviewInternational journal of obesity supplements2019
Obesity and hypovitaminosis D: causality or casualty?
Review in International journal of obesity supplements, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis.Endocrine · 2021Pooled it
- Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Efficacy of Vitamin DNutrients · 2020Pooled it
- Trial
- Review
- Vitamin D and exercise in obesity: a neurovascular-muscle axis.Frontiers in nutrition · 2026Review
- The location of physical activity determines its efficacy on Vitamin D status: Evidence from a meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Review
- The impact of dietary and lifestyle factors on obesity among chinese children during the first 6 years of life: a 2014-2015 multi-centre study.Frontiers in nutrition · 2026Article
- Vitamin D in the elderly: the phil-rouge in preventing bone, muscle and adipose deterioration?Archives of endocrinology and metabolism · 2025Review
- Defective lymphatic vasculature in obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Mediating role of inflammatory markers (NLR, PLR, SII, SIRI) in the association between 25(OH)D deficiency and obesity in children and adolescents.Journal of health, population, and nutrition · 2025Article
- Lipid Profile Alterations in Pediatric Patients with Vitamin D Deficiency.Children (Basel, Switzerland) · 2025Article
- Customizing Nutrients: Vitamin D and Iron Deficiencies in Overweight and Obese Children-Insights from a Romanian Study.Nutrients · 2025Observational
- Cholecalciferol vs. calcifediol supplementation on visceral adiposity in people with obesity: a real-world retrospective study.Frontiers in nutrition · 2025Article
- 1,25‑Dihydroxyvitamin D3 mitigates the adipogenesis induced by bisphenol A in 3T3-L1 and hAMSC through miR-27-3p regulation.International journal of obesity (2005) · 2024Article
- Prediction of hospitalization time probability for COVID-19 patients with statistical and machine learning methods using blood parameters.Annals of medicine and surgery (2012) · 2024Article
- Vitamin D Deficiency: Insights and Perspectives from a Five-Year Retrospective Analysis of Children from Northeastern Romania.Nutrients · 2024Article
- Metabolic Syndrome, Inflammation, Oxidative Stress, and Vitamin D Levels in Children and Adolescents with Obesity.International journal of molecular sciences · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies reported that vitamin D deficiency represents an increasingly widespread phenomenon in various populations. Vitamin D deficiency is considered a clinical syndrome determined by low circulating levels of 25-hydroxyvitamin D (25(OH)D), which is the biologically-inactive intermediate and represents the predominant circulating form. Different mechanisms have been hypothesized to explain the association between hypovitaminosis D and obesity, including lower dietary intake of vitamin D, lesser skin exposure to sunlight, due to less outdoor physical activity, decreased intestinal absorption, impaired hydroxylation in adipose tissue and 25(OH)D accumulation in fat. However, several studies speculated that vitamin D deficiency itself could cause obesity or prevent weight loss. The fat-solubility of vitamin D leads to the hypothesis that a sequestration process occurs in body fat depots, resulting in a lower bioavailability in the obese state. After investigating the clinical aspects of vitamin D deficiency and the proposed mechanisms for low 25(OH)D in obesity, in this manuscript we discuss the possible role of vitamin D replacement treatment, with different formulations, to restore normal levels in individuals affected by obesity, and evaluate potential positive effects on obesity itself and its metabolic consequences. Food-based prevention strategies for enhancement of vitamin D status and, therefore, lowering skeletal and extra-skeletal diseases risk have been widely proposed in the past decades; however pharmacological supplementation, namely cholecalciferol and calcifediol, is required in the treatment of vitamin D insufficiency and its comorbidities. In individuals affected by obesity, high doses of vitamin D are required to normalize serum vitamin D levels, but the different liposolubility of different supplements should be taken into account. Although the results are inconsistent, some studies reported that vitamin D supplementation may have some beneficial effects in people with obesity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.