Evidence map›Paper›PMID 31391894›Full record

ArticleMedChemComm2019

Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues.

Alhanouf Z Aljahdali, Seth A Freedman, Jana Scott, Miaosheng Li, George A O'Doherty

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alhanouf Z AljahdaliDept. of Chemistry and Chem. Bio , Northeastern Univ. Boston , MA 02115 , USA . Email: g.odoherty@neu.edu.ORCID 0000-0002-6319-9702
Seth A FreedmanDept. of Chemistry and Chem. Bio , Northeastern Univ. Boston , MA 02115 , USA . Email: g.odoherty@neu.edu.ORCID 0000-0002-9813-8539
Jana ScottDept. of Chemistry , Univ. of Minnesota , Minneapolis , MN 55455 , USA.
Miaosheng LiDept. of Chemistry , West Virginia Univ. Morgantown , WV 26506 , USA.
George A O'DohertyDept. of Chemistry and Chem. Bio , Northeastern Univ. Boston , MA 02115 , USA . Email: g.odoherty@neu.edu.ORCID 0000-0002-1699-2249
Northeastern University · USUniversity of Minnesota · USWest Virginia University · US

Funding

Apramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogensR21AI142040 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$476k
Targeted modification of the apramycin 2-deoxystreptamine ring to block aminoglycoside modifying enzyme-based inactivation and enhance potency against multidrug-resistant Gram-negative pathogensR03AI144196 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$183k
NIAID NIH HHS R03 AI144196NIAID NIH HHS R21 AI142040
6 · The paper itself

Abstract

The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2-50 μM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.

Identifiers

PMID31391894
PMCPMC6640558
OpenAlexW2944399886

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.