Evidence map›Paper›PMID 31391881›Full record

ArticleMedChemComm2019

Pyrazolo[4,3-

Stephanie Federico, Enrico Margiotta, Silvia Paoletta, Sonja Kachler, Karl-Norbert Klotz, Kenneth A Jacobson, Giorgia Pastorin, Stefano Moro, Giampiero Spalluto

Abstract read
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Journal of medicinal chemistry · 2023
    Article
  2. Potent and selective ARSC medicinal chemistry · 2021
    Article
  3. Conjugable AEuropean journal of medicinal chemistry · 2020
    Article
  4. Chemical Probes for the Adenosine Receptors.Pharmaceuticals (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Stephanie FedericoDepartment of Chemical and Pharmaceutical Sciences , University of Trieste , Via Licio Giorgeri 1 , 34127 Trieste , Italy . Email: sfederico@units.it.ORCID 0000-0003-2800-5287
Enrico MargiottaMolecular Modeling Section (MMS) , Dipartimento di Scienze del Farmaco , Università degli Studi di Padova , Via F. Marzolo 5 , 35131 Padova , Italy.
Silvia PaolettaMolecular Modeling Section (MMS) , Dipartimento di Scienze del Farmaco , Università degli Studi di Padova , Via F. Marzolo 5 , 35131 Padova , Italy.
Sonja KachlerInstitut für Pharmakologie und Toxicologie , Universität Würzburg , Versbacher Straße 9 , 97078 Würzburg , Germany.
Karl-Norbert KlotzInstitut für Pharmakologie und Toxicologie , Universität Würzburg , Versbacher Straße 9 , 97078 Würzburg , Germany.ORCID 0000-0003-3553-3205
Kenneth A JacobsonLaboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bethesda , Maryland 20892-0810 , USA.ORCID 0000-0001-8104-1493
Giorgia PastorinDepartment of Pharmacy , National University of Singapore , 3 Science Drive 3 , 117543 Singapore.ORCID 0000-0002-2568-0626
Stefano MoroMolecular Modeling Section (MMS) , Dipartimento di Scienze del Farmaco , Università degli Studi di Padova , Via F. Marzolo 5 , 35131 Padova , Italy.ORCID 0000-0002-7514-3802
Giampiero SpallutoDepartment of Chemical and Pharmaceutical Sciences , University of Trieste , Via Licio Giorgeri 1 , 34127 Trieste , Italy . Email: sfederico@units.it.ORCID 0000-0002-1957-7155
University of Padua · ITUniversity of Trieste · ITUniversity of Würzburg · DENational Institutes of Health · USNational University of Singapore · SG

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Functionalized Congeners Of Bioactive CompoundsZIADK031115 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$5.3M
6 · The paper itself

Abstract

A series of adenosine receptor antagonists bearing a reactive linker was developed. Functionalization of these derivatives is useful to easily obtain multi-target ligands, receptor probes, drug delivery systems, and diagnostic or theranostic systems. The pyrazolo[4,3-

Identifiers

PMID31391881
PMCPMC6644567
OpenAlexW2913387966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.