Evidence map›Paper›PMID 31391767›Full record

ReviewWorld journal of gastroenterology2019

Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma.

Clifford Akateh, Sylvester M Black, Lanla Conteh, Eric D Miller, Anne Noonan, Eric Elliott, Timothy M Pawlik, Allan Tsung, Jordan M Cloyd

3 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04521153 phase2 / phase3active not recruitingnot on this mapstarted 2021, after this paper: background citation

Camrelizumab Combined With Apatinib Mesylate for Perioperative Treatment of Resectable Hepatocellular Carcinoma:a Randomized, Open-label, Parallel, Multicenter Trial

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2021 to 2026Enrolled294ConditionsHepatocellular Carcinoma, Immunotherapy, Molecular Targeted TherapyArmsCamrelizumab, Apatinib Mesylate, Radical surgery
NCT05161143 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Efficacy and Safety of Donafenib Combined With TACE as Adjuvant Therapy of Patients With Hepatocellular Carcinoma at a High Risk of Recurrence After Radical Resection

TypeinterventionalSponsorPeking Union Medical College HospitalRan2021 to 2024Enrolled30ConditionsHepatocellular CarcinomaArmsDonafenib
NCT06143579 phase2not yet recruitingnot on this mapstarted 2023, after this paper: background citation

FOLFOX-Hepatic Arterial Infusion Chemotherapy (HAIC) Combined With Lenvatinib and Envolizumab in Potentially Resectable Hepatocellular Carcinoma:A Single-arm, Open-label, Single Center, Phase II Trial

TypeinterventionalSponsorSun Yat-sen UniversityRan2023 to 2026Enrolled48ConditionsPotentially Resectable Hepatocellular CarcinomaArmsFOLFOX-HAIC+Lenvatinib+Envolizumab
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Clifford AkatehDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Sylvester M BlackDivision of Transplant Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Lanla ContehDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Eric D MillerDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Anne NoonanDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Eric ElliottDivision of Diagnostic Radiology, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Timothy M PawlikDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Allan TsungDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Jordan M CloydDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States. jordan.cloyd@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
NIAID NIH HHS T32 AI106704
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or

Indexed as

HepatectomyAblation TechniquesAntineoplastic Combined Chemotherapy ProtocolsAntiviral AgentsCarcinoma, HepatocellularChemoembolization, TherapeuticChemotherapy, AdjuvantHumansLiverLiver NeoplasmsNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingRadiosurgeryTreatment OutcomeYttrium RadioisotopesAntiviral AgentsYttrium-90Yttrium RadioisotopesAdjuvant therapyHepatectomyHepatocellular carcinomaLiver cirrhosisNeoadjuvant therapyNeoplasm recurrence

Identifiers

PMID31391767
PMCPMC6676544
OpenAlexW2966472134

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.