Evidence map›Paper›PMID 31391614›Full record

ReviewIndian journal of anaesthesia2019

Role of topical magnesium in post-operative sore throat: A systematic review and meta-analysis of randomised controlled trials.

Narinder P Singh, Jeetinder K Makkar, Vincent Wourms, Andrés Zorrilla-Vaca, Ronald B Cappellani, Preet M Singh

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Indian journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Narinder P SinghDepartment of Anesthesia Perioperative and Pain Medicine, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Jeetinder K MakkarDepartment of Anesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Vincent WourmsDepartment of Anesthesia Perioperative and Pain Medicine, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Andrés Zorrilla-VacaSchool of Medicine, Faculty of Health, Universidad del Valle, Hospital Universidad del Valle, Cali, Colombia.
Ronald B CappellaniDepartment of Anesthesia Perioperative and Pain Medicine, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Preet M SinghDepartment of Anesthesia, Washington University, St Louis, MO, USA.
Post Graduate Institute of Medical Education and Research · INWashington University in St. Louis · USUniversidad del Valle · COUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPost-operative sore throat (POST) is a common undesirable consequence of tracheal intubation. Magnesium, an N-methyl-D-aspartate receptor antagonist, has anti-nociceptive and anti-inflammatory properties, and has been found to be useful in POST prevention in various trials. We conducted this systematic review and meta-analysis to study the efficacy of topical magnesium in preventing POST in adult patients undergoing surgery under general anaesthesia with single lumen tracheal tube.

methodsComprehensive literature search was performed in PubMed, Google Scholar, EMBASE, Scopus and the Cochrane central registers of controlled trial databases through July, 2018 and data were pooled using fixed effect modelling followed by random-effect methods (after assessing heterogeneity with fixed modelling). The primary outcome was the incidence of POST at 24 h after surgery/extubation. Comparative results were deliberated as pooled mean difference for continuous variables and Mantel-Haenszel (MH) odds ratio for dichotomous variables. Statistical analysis was done using Comprehensive Meta-Analysis-Version 3 (Biostat Inc., USA).

resultsSeven trials involving 726 study participants were included in the final analysis. Incidence of POST at 24 hours was significantly lower in magnesium group (26/363) in comparison to active and non-active control group (89/363);

conclusionProphylactic use of topical magnesium before the induction of general anaesthesia seems to be an effective measure to decrease the incidence of POST.

Indexed as

Magnesium sulphatemeta-analysismpostoperative sore throatsystematic reviewtopical

Identifiers

PMID31391614
PMCPMC6644199
OpenAlexW2956711235

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.